Results 21 to 30 of about 12,154 (204)

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated.
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, Claudiu T. Supuran   +8 more
doaj   +1 more source

Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of α-Glucosidase and Urease

Molecules, 2022
A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, 1H-NMR, 13C-NMR, and HREI-MS ...
Shoaib Khan, Shahid Iqbal, Mazloom Shah, Wajid Rehman, Rafaqat Hussain, Liaqat Rasheed, Hamad Alrbyawi, Ayed A. Dera, Mohammed Issa Alahmdi, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk   +11 more
doaj   +1 more source

Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities.
Guangcheng Wang, Meiyan Fan, Wenjing Liu, Min He, Yongjun Li, Zhiyun Peng   +5 more
doaj   +1 more source

Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs.
Kun Tang, Huan-Huan Li, Chengyao Wu, Shi-Long Zhang, Jian-Guo Yang, Wenjian Tang, Hua-Li Qin   +6 more
doaj   +1 more source

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
Andrea Angeli, Claudiu T. Supuran
doaj   +1 more source

Synthesis and evaluation of sulphonamide clubbed thiophenes as dihydrogen pteroate synthase inhibitors [PDF]

, 2023
Background. Derivatives of thiophene and sulphonamide showed various pharmacological activities including antimicrobial and dihydrofolate reductase (DHFR) inhibition activity. Dihydrofolate reductase and dihydropteroate synthetase enzymes are responsible
Chawla, Pooja A., Kaur, Rupinder
core   +1 more source

Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen Trichomonas vaginalis encodes two such enzymes belonging to the β-class, TvaCA1 and TvaCA2.
Linda J. Urbański, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila, Claudiu T. Supuran   +6 more
doaj   +1 more source

Determination of Sulphonamides and Tetracycline Residues in Liver Tissues of Broiler Chicken Sold in Kinondoni and Ilala Municipalities, Dar es Salaam, Tanzania

Antibiotics, 2022
In Tanzania, the increased demand for animal-derived foods, particularly eggs, meat, and milk, has resulted in the intensification of farming systems with the use of antimicrobials, particularly sulphonamides and tetracyclines.
Winstone J. Ulomi, Fauster X. Mgaya, Zuhura Kimera, Mecky I. Matee   +3 more
doaj   +1 more source

Combined chlorination and nanofiltration to enhance removal efficiencies of sulphonamide in simulated wastewater / Mohd Redzuan Ramli [PDF]

, 2015
Rapid advancement in healthcare and manufacturing industries has resulted in the introduction of new potentially harmful chemicals such as endocrine disrupting chemicals (EDCs) and pharmaceutically active compounds (PhACs) from wastewater produced by ...
Mohd Redzuan, Ramli
core   +2 more sources

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

Molecules, 2010
A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity.
Fidel Martínez-Gutiérrez, Francisco Méndez, Roberto Martínez, Marco Martín González-Chávez, Cuaúhtemoc Pérez-González   +4 more
doaj   +1 more source