Results 41 to 50 of about 13,917 (157)

Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs – a joint docking/molecular dynamics study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The binding mode of aromatic sulphonamides and clinically licenced drugs to the three carbonic anhydrase (CA, EC 4.2.1.1) isoforms from the human pathogen V.
Alessandro Bonardi, Alessio Nocentini, Sameh Mohamed Osman, Fatmah Ali Alasmary, Tahani Mazyad Almutairi, Dalal Saied Abdullah, Paola Gratteri, Claudiu T. Supuran   +7 more
doaj   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors.
D. Zelencova-Gopejenko, V. Andrianov, I. Domracheva, I. Kanepe-Lapsa, M. Milczarek, M. Stojak, K. Przyborowski, F. A. Fedak, M. Walczak, K. Kramkowski, J. Wietrzyk, S. Chlopicki, I. Kalvins   +12 more
doaj   +1 more source

Predictors of clinically significant bleeding in dogs with severe thrombocytopenia: 159 cases (2012‐2021)

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate risk factors for clinically significant bleeding in dogs with severe thrombocytopenia and to assess whether predictors of bleeding differ between immune thrombocytopenia and other causes, and whether platelet mass is more predictive than platelet count.
G. Smith, E. D. Bennet, A. E. Ridyard
wiley   +1 more source

Evaluation of ELISA tests as screening methods for determination of antibiotics and sulfonamides in honey [PDF]

Food and Feed Research, 2018
The health safety of honey includes the correctness in terms of the presence of different contaminants, which also implies the antibiotic residue. The presence of antibiotics in honey is prohibited, and methods of food analysis are prescribed in order to
Jakšić Sandra M., Mihaljev Željko A., Kartalović Brankica D., Babić Jelena B., Vidaković Suzana L., Baloš-Živkov Milica M.   +5 more
doaj  

Bacterial Diseases in Farmed Nile Tilapia (Oreochromis niloticus): A Review of Pathogenesis, Immune Responses and Recent Advances in Diagnostics and Management

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
Pathogenesis of bacterial diseases in Nile tilapia and anti‐bacterial mechanisms. ABSTRACT Nile tilapia (Oreochromis niloticus) is among the most widely farmed fish globally that plays a major role in ensuring food security in many low‐ and middle‐income countries.
Catherine Agoe, John Walakira, Gerald Kwikiriza, Nasser Kasozi, Ivan Abaho, Manuel Curto, Paul Meulenbroek, Harald Meimberg, Peter Akoll   +8 more
wiley   +1 more source

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities.
Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, Abdelrahman I. Zain-Alabdeen, Zainab M. Elsayed, Eslam B. Elkaeed, Rofaida Salem, Claudiu T. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik   +11 more
doaj   +1 more source

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1101-1110, October 2026.
NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben, David W. Hein, Michelle Whirl‐Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A. G. Agúndez, Kelly E. Caudle   +10 more
wiley   +1 more source

INFLUENCE OF SULPHONAMIDES ON FIBROBLASTS

, 1945
The toxicity of several sulphonamides for tissue cells has been tested by adding the compounds to tissue cultures of fibroblasts (guinea pig heart tissue in guinea pig serum).
Reta Anderson, J. H. Orr, G. B. Reed
core   +1 more source

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Miranda E. Pitt, Jianshu Zhang, An N. T. Nguyen, Michael B. Hall, Leila Jebeli, Leo A. Featherstone, Garry S. A. Myers, Nichollas E. Scott, Lachlan J. M. Coin   +8 more
wiley   +1 more source