Results 21 to 30 of about 13,917 (157)

Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

Pharmaceuticals, 2021
New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides. These sulphonamides were investigated as human carbonic anhydrases (hCAs, EC 4.2.1.1) I, II, IX, and XII inhibitors.
Kalyan K. Sethi, KM Abha Mishra, Saurabh M. Verma, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran   +5 more
doaj   +1 more source

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A library of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates was synthesised by selective S-alkylation of the easily accessible 4-thioureidobenzenesulphonamide.
Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran, Raivis Žalubovskis   +3 more
doaj   +1 more source

2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A small library of substituted cyclic guanidine incorporated benzothiazole-6-sulphonamides was synthesized. All obtained compounds were investigated for their inhibitory activity against the key brain-associated human carbonic anhydrase isoform hCA VII ...
Morteza Abdoli, Claudiu T. Supuran, Raivis Žalubovskis   +2 more
doaj   +1 more source

Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.
Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda, Renata Kontek   +6 more
doaj   +1 more source

Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Warm-blooded animals may have Malassezia pachydermatis on healthy skin, but changes in the skin microenvironment or host defences induce this opportunistic commensal to become pathogenic.
Viviana De Luca, Andrea Angeli, Valeria Mazzone, Claudia Adelfio, Vincenzo Carginale, Andrea Scaloni, Fabrizio Carta, Silvia Selleri, Claudiu T. Supuran, Clemente Capasso   +9 more
doaj   +1 more source

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised.
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Manuel Medarde, Rogelio González-Sarmiento, Rafael Peláez   +5 more
doaj   +1 more source

Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A β-class carbonic anhydrase (CA, EC 4.2.1.1) present in the genome of the Monogenean platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its inhibitory effects with a panel of sulphonamides and sulfamates, some of ...
Ashok Aspatwar, Alessandro Bonardi, Heidi Aisala, Ksenia Zueva, Craig R Primmer, Jaakko Lumme, Seppo Parkkila, Claudiu T. Supuran   +7 more
doaj   +1 more source

Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes involved in biosynthetic processes, transport, supply, and balance of CO2/HCO3- into the cell.
Sonia Del Prete, Silvia Bua, Claudiu T. Supuran, Clemente Capasso   +3 more
doaj   +1 more source

Antimicrobial Resistance Among Selected Zoonotic Bacteria: A Case Study of Tortoises and Birds at the Uganda Wildlife Conservation Education Centre. [PDF]

Vet Med Sci
This study investigated antimicrobial resistance in birds and tortoises at the Uganda Wildlife Conservation Education Centre. Escherichia coli predominated in birds, whereas Salmonella enteritidis predominated in tortoises with resistance to sulphonamides detected.
Namara DD, Ssajjakambwe P, Nakabuye SR, Katabazi VA, Sente C.   +4 more
europepmc   +2 more sources

Synthesis of spiroheterocycles by oxidation of sulphonamides [PDF]

, 1981
The oxidation of l-benzyl-l, 2,3,4-tetrahydroisoq'uinoline-1-carboxylic acids to isoquinaldic spirodlenelactones and the reaction of these with nucleophiles may provide an efficient route to substituted benzylisoquinolines and to bisbenzylisoquinolines ...
Musto, DR
core   +5 more sources