Results 91 to 100 of about 163,760 (356)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Bounds for the stop-loss distance of an independent random sum via Stein's method

AIMS Mathematics
Let $ W = X_1+X_2+\cdots + X_N $ be a random sum and $ Z $ be the standard normal random variable. In this paper, we investigated uniform and non-uniform bounds of the stop-loss distance, which measures the difference between two random variables, $ W ...
Punyapat Kammoo, Kritsana Neammanee, Kittipong Laipaporn   +2 more
doaj   +1 more source

A Novel Stochastic Model for IRS-Assisted Communication Systems Based on the Sum-Product of Nakagami-m Random Variables [PDF]

IEEE Open Journal of the Communications Society
This paper presents exact formulas for the probability distribution function (PDF) and moment generating function (MGF) of the sum-product of statistically independent but not necessarily identically distributed (i.n.i.d.) Nakagami-m random variables ...
Hamid Amiriara, Mahtab Mirmohseni, Farid Ashtiani, M. Nasiri-Kenari, B. Maham   +4 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Lundberg-type inequality for an inhomogeneous renewal risk model

Modern Stochastics: Theory and Applications, 2015
We obtain a Lundberg-type inequality in the case of an inhomogeneous renewal risk model. We consider the model with independent, but not necessarily identically distributed, claim sizes and the interoccurrence times.
Ieva Marija Andrulytė, Emilija Bernackaitė, Dominyka Kievinaitė, Jonas Šiaulys   +3 more
doaj   +1 more source

Improved concentration bounds for sums of independent sub-exponential random variables [PDF]

, 2022
Iosif Pinelis
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Limit theorems for random Dirichlet series: boundary case

Modern Stochastics: Theory and Applications
Buraczewski et al. (2023) proved a functional limit theorem (FLT) and a law of the iterated logarithm (LIL) for a random Dirichlet series ${\textstyle\sum _{k\ge 2}}\frac{{(\log k)^{\alpha }}}{{k^{1/2+s}}}{\eta _{k}}$ as $s\to 0+$, where $\alpha \gt -1/2$
Alexander Iksanov, Ruslan Kostohryz
doaj   +1 more source

Inequalities for sums of independent random variables in Lorentz spaces [PDF]

, 2015
Ghadir Sadeghi
openalex   +1 more source