Results 211 to 220 of about 50,255 (242)
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Virus Research, 2003
To find cellular binding counterparts for the nucleocapsid protein (N) of Tula hantavirus (TULV), two cDNA libraries were screened using yeast two-hybrid systems based on LexA and Gal4 transcription factors. Five cDNA clones encoding SUMO-1 (Small Ubiquitin-related MOdifier, also known as sentrin) were selected in the LexA system.
Pasi, Kaukinen +2 more
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To find cellular binding counterparts for the nucleocapsid protein (N) of Tula hantavirus (TULV), two cDNA libraries were screened using yeast two-hybrid systems based on LexA and Gal4 transcription factors. Five cDNA clones encoding SUMO-1 (Small Ubiquitin-related MOdifier, also known as sentrin) were selected in the LexA system.
Pasi, Kaukinen +2 more
openaire +2 more sources
Molecular Reproduction and Development, 2005
The small ubiquitin-related modifier-1 (SUMO-1) with broad cellular expression has been implicated in a range of cellular processes, such as cell proliferation, differentiation, and apoptosis. As shown recently, SUMO-1 is expressed and regulated by gonadotropins, in particular an ovulatory hCG stimulus in mouse granulosa cells in vivo.
Ruijin, Shao +3 more
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The small ubiquitin-related modifier-1 (SUMO-1) with broad cellular expression has been implicated in a range of cellular processes, such as cell proliferation, differentiation, and apoptosis. As shown recently, SUMO-1 is expressed and regulated by gonadotropins, in particular an ovulatory hCG stimulus in mouse granulosa cells in vivo.
Ruijin, Shao +3 more
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SUMO-1 overexpression increases RbAp46 protein stability and suppresses cell growth.
Anticancer research, 2009The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a nuclear protein of 46 kDa and contains four repeats that end with Trp-Asp (WD) residues. In this study, we reveal that the RbAp46 protein level upon SUMO-1 expression was increased. The increasing level of RbAp46 protein by SUMO-1 was not regulated at the transcriptional level. SUMO-
Raghavaraju, Giri +3 more
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Journal of Virology, 1999
ABSTRACTPML nuclear bodies (NBs) are subnuclear structures whose integrity is compromised in certain human diseases, including leukemia and neurodegenerative disorders. Infection by a number of DNA viruses similarly triggers the reorganization of these structures, suggesting an important role for the NBs in the viral infection process. While expression
Müller, Stefan, Dejean, Anne
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ABSTRACTPML nuclear bodies (NBs) are subnuclear structures whose integrity is compromised in certain human diseases, including leukemia and neurodegenerative disorders. Infection by a number of DNA viruses similarly triggers the reorganization of these structures, suggesting an important role for the NBs in the viral infection process. While expression
Müller, Stefan, Dejean, Anne
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American Journal of Medical Genetics Part A, 2005
AbstractThe ICF syndrome (immunodeficiency, centromeric instability, facial anomalies) (OMIM#242860) is a rare autosomal, recessively inherited disorder. Another rare condition, ischiadic hypoplasia, renal dysgenesis, immunodeficiency, and polydactyly (IHRDIP, OMIM#243340), displays features that resemble those of the ICF syndrome.
Kloeckener-Gruissem, Barbara +4 more
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AbstractThe ICF syndrome (immunodeficiency, centromeric instability, facial anomalies) (OMIM#242860) is a rare autosomal, recessively inherited disorder. Another rare condition, ischiadic hypoplasia, renal dysgenesis, immunodeficiency, and polydactyly (IHRDIP, OMIM#243340), displays features that resemble those of the ICF syndrome.
Kloeckener-Gruissem, Barbara +4 more
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Biochemical Genetics, 2005
In fission yeast (Schizosaccharomyces pombe) the homologue of the mammalian SUMO-1 ubiquitin-like modifier is encoded by the pmt3 gene. A two-hybrid screen using the telomere-binding protein Taz1p as bait identified Pmt3p as an interacting factor. In vitro experiments using purified components of the fission yeast Pmt3p modification system demonstrated
K, Spink +4 more
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In fission yeast (Schizosaccharomyces pombe) the homologue of the mammalian SUMO-1 ubiquitin-like modifier is encoded by the pmt3 gene. A two-hybrid screen using the telomere-binding protein Taz1p as bait identified Pmt3p as an interacting factor. In vitro experiments using purified components of the fission yeast Pmt3p modification system demonstrated
K, Spink +4 more
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Biochemical and Biophysical Research Communications, 2005
The HIPK2 protein is a critical regulator of apoptosis and functionally interacts with p53 to increase gene expression. Here we show that human HIPK2 is modified by sumoylation at lysine 25, as revealed by in vivo and in vitro experiments. While SUMO-1 modification of HIPK2 has no influence on its ability to phosphorylate p53 at serine 46, to induce ...
Ekaterina, Gresko +3 more
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The HIPK2 protein is a critical regulator of apoptosis and functionally interacts with p53 to increase gene expression. Here we show that human HIPK2 is modified by sumoylation at lysine 25, as revealed by in vivo and in vitro experiments. While SUMO-1 modification of HIPK2 has no influence on its ability to phosphorylate p53 at serine 46, to induce ...
Ekaterina, Gresko +3 more
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Examining the Potential Modification of the Protein Tyrosine Kinase Pyk2 by SUMO-1
2013Proline-rich tyrosine kinase 2 (Pyk2) is a non-receptor protein tyrosine kinase that is highly expressed in hematopoietic cells. Our lab generated two polyclonal antibodies to investigate the regulation of Pyk2 in macrophages and T cells. In macrophages the N-terminal antibody immunoprecipitated a higher molecular weight form of Pyk2.
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BIOCHEMICAL CHARACTERIZATIONS OF SUMO-1 CONJUGATION WITH PROTEINS IN XENOPUS EGG EXTRACTS
1999SUMO-1 (Small Ubiquitin-related Modifer) is a small ubiquitin-related protein. Like ubiquitin, it can be covalently attached to other proteins via an isopeptide bond between its C-terminal glycine residue and lysine residues of substrate proteins. Conjugation of ubiquitin requires the activities of ubiquitin-activating El and ubiquitin-conjugating E2 ...
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Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli
Analytical Biochemistry, 2004Yasuhiro, Uchimura +4 more
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