Results 101 to 110 of about 291,935 (374)

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, EarlyView.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells

Cellular Physiology and Biochemistry, 2017
Background: It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo.
Lifang Jin, Kexin Shen, Tong Chen, Wei Yu, Huaiyu Zhang   +4 more
doaj   +1 more source

Runs make the bank : The fragile capital structure of banks make them inevitably prone to runs, and that's a good thing [PDF]

Banks and ...
Vanessa Sumo
core  

A new prokaryotic expression vector for the expression of antimicrobial peptide abaecin using SUMO fusion tag

BMC Biotechnology, 2019
BackgroundDespite the growing demand for antimicrobial peptides (AMPs) for clinical use as an alternative approach against antibiotic-resistant bacteria, the manufacture of AMPs relies on expensive, small-scale chemical methods.
Da Sol Kim, Seon Woong Kim, Jaemahn Song, Soon-Young Kim, Kwang-Chul Kwon   +4 more
semanticscholar   +1 more source

SUMO on the road to neurodegeneration

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
Sumoylation is a post-translational modification by which small ubiquitin-like modifiers (SUMO) are covalently conjugated to target proteins. This reversible pathway provides a rapid and efficient way to modulate the subcellular localization, activity and stability of a wide variety of substrates.
Véronique Dorval, Paul E. Fraser
openaire   +3 more sources

Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, EarlyView.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

On the home front : housing markets cool off in some states but not in others [PDF]

Housing ...
Vanessa Sumo
core  

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4 [PDF]

, 2014
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response.
A Hershko, A Plechanovova, A Plechanovova, A Rojas-Fernandez, AM Weissman, AT Brunger, AT Namanja, CC Chang, CH Cheng, CM Hecker, CM Pickart, CW Liew, D Reverter, E Escobar-Cabrera, ES Johnson, F Ikeda, FM Lin, GNB Yip, H Sun, HD Ulrich, HY Sun, I Matic, J Marchant, J Prudden, J Song, J Song, J Xia, JD Schnell, JH Hurley, JL Battiste, JS Thrower, K Keusekotten, L Deng, M Ottiger, M Zweckstetter, MH Tatham, MH Tatham, MJ Eddins, MJ Eddins, MR Hansen, MS Rodriguez, N Sekiyama, N Zhang, O Kerscher, O Kerscher, Q Wang, R Bruderer, R Lescasse, R Mahajan, R Varadan, RT Hay, S-R Tzeng, SC Panchal, W Rieping, W-C Huang, XD Zhang, Y Shen, Y Xie   +57 more
core   +4 more sources

SUMO enters the ring [PDF]

Journal of Cell Biology, 2015
In 1996, Matunis et al. were one of several groups to identify a novel, ubiquitin-like protein modification.
openaire   +3 more sources

Comparative Structural Analysis of Escherichia Coli Cyay at Room and Cryogenic Temperatures Using Macromolecular and Serial Crystallography

ChemBioChem, EarlyView.
Room‐temperature (RT) crystallography of E. coli CyaY, the bacterial frataxin homolog, reveals subtle but functionally relevant differences from cryogenic structures. The conserved fold shows distinct side‐chain conformations and water networks, highlighting dynamics often hidden at low temperatures.
Alaleh Shafiei, Nilufer Baldir, Jongbum Na, Jin Hae Kim, Hasan DeMirci   +4 more
wiley   +1 more source