Results 161 to 170 of about 291,935 (374)
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
The FEBS Journal, EarlyView.Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain +2 more
wiley +1 more source
Strategies to Identify Recognition Signals and Targets of SUMOylation
Biochemistry Research International, 2012 SUMOylation contributes to the regulation of many essential cellular factors. Diverse techniques have been used to explore the functional consequences of protein SUMOylation.
Elisa Da Silva-Ferrada +4 more
doaj +1 more source
SUMO-1 Conjugation to Human DNA Topoisomerase II Isozymes [PDF]
, 2000 Yong Mao, Shyamal D. Desai, Leroy F. Liu
openalex +1 more source
Unconventional structure and function of PHD domains from additional sex combs‐like proteins
The FEBS Journal, EarlyView.A plant homeodomain (PHD) at the C terminus of additional sex combs‐like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifications. Instead, a complex between the ASXL PHD and methyl CpG‐binding domain proteins 5 and 6 (MBD5/6) was investigated.
Cameron J. Reddington +4 more
wiley +1 more source
Memories, Ghosts, and Scars: Architecture and Trauma in New York and Hiroshima
Journal of Transnational American Studies, 2011 Sunil Bald
doaj +1 more source
SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53 [PDF]
, 2000 Thomas Buschmann +4 more
openalex +1 more source
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, EarlyView.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source