Results 31 to 40 of about 300,823 (367)
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype
Gut, 2020 Objective Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with an overall 5-year survival rate of 9%. Conventional combination chemotherapies are a clear advance in the treatment of PDAC; however, subtypes of the disease exist ...
Alexander Biederstädt +26 more
semanticscholar +1 more source
SUMO-Conjugating and SUMO-Deconjugating Enzymes from Arabidopsis [PDF]
Plant Physiology, 2006 Abstract Posttranslational protein modification by the small ubiquitin-like modifier (SUMO) is a highly dynamic and reversible process. To analyze the substrate specificity of SUMO-conjugating and -deconjugating enzymes from Arabidopsis (Arabidopsis thaliana), we reconstituted its SUMOylation cascade in vitro and tested the capacity of ...
Colby, T. +3 more
openaire +3 more sources
Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility
Nature Communications, 2020 The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers.
Chongyang Li +7 more
semanticscholar +1 more source
Biotechnology & Biotechnological Equipment, 2019 The present study investigated the role and mechanism of SUMO2/3 in the protection of vascular endothelial cells by propofol. An ischemia-reperfusion (I/R) injury model of human umbilical vein endothelial cells (HUVECs) was constructed.
Peng Li +3 more
doaj +1 more source
Heliyon, 2023 Information and communication technology graduates are among the highly skilled, paid, and perceived as capable and credible professionals worldwide. This has resonated in significant growth in the number of students pursuing careers in ICT at various ...
Dorris Zayzay Sumo +2 more
doaj +1 more source
SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases [PDF]
Cell Reports, 2016 Post-translational modification of proteins with ubiquitin-like SUMO modifiers is a tightly regulated and highly dynamic process. The SENP family of SUMO-specific isopeptidases comprises six cysteine proteases. They are instrumental in counterbalancing SUMO conjugation, but their regulation is not well understood.
Kunz Kathrin +5 more
openaire +5 more sources
Sequential sampling strategy for the modeling of parameterized microwave and RF components [PDF]
, 2011 Accurate modeling of parameterized microwave and RF components often requires a large number of full-wave electromagnetic simulations. In order to reduce the overall simulation cost, a sequential sampling algorithm is proposed that selects a sparse set ...
Crombecq, Karel +3 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2020 The Sgs1 helicase and Top3-Rmi1 decatenase form a complex that affects homologous recombination outcomes during the mitotic cell cycle and during meiosis.
Matan Cohen, Michael Lichten
doaj +1 more source
Logi, 2022 Green corridor is a dynamic real-time lane created in order to increase the speed at which an emergency vehicle can travel in traffic. Its purpose is to reduce the travel time of emergency vehicles.
Yadav Shalini, Rishi Rahul
doaj +1 more source
Nature Communications, 2020 Nuclear Pore complexes (NPCs) act as docking sites to anchor particular DNA lesions facilitating DNA repair by elusive mechanisms. Using replication fork barriers in fission yeast, we report that relocation of arrested forks to NPCs occurred after Rad51 ...
Karol Kramarz +7 more
semanticscholar +1 more source