Results 61 to 70 of about 300,823 (367)

Spin‐Split Edge States in Metal‐Supported Graphene Nanoislands Obtained by CVD

Advanced Materials, EarlyView.
Combining STM measurements and ab‐initio calculations, we show that zig‐zag edges in graphene nanoislands grown on Ni(111) by CVD retrieve their spin‐polarized edge states after intercalation of a few monolayers of Au. ABSTRACT Spin‐split states localized on zigzag edges have been predicted for different free‐standing graphene nanostructures.
Michele Gastaldo, Masoud Mansouri, Carlos Garcia‐Fernandez, Daniel Sánchez‐Portal, Aran Garcia‐Lekue, Gustavo Ceballos, Aitor Mugarza   +6 more
wiley   +1 more source

A Photo-Crosslinking Approach to Identify Class II SUMO-1 Binders

Frontiers in Chemistry, 2022
The small ubiquitin-like modifier (SUMO) is involved in various cellular processes and mediates known non-covalent protein-protein interactions by three distinct binding surfaces, whose interactions are termed class I to class III.
Kira Brüninghoff, Stephanie Wulff, Wolfgang Dörner, Ruth Geiss-Friedlander, Henning D. Mootz   +4 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Development of a Middleware between SUMO simulation tool and JaCaMo framework

Advances in Distributed Computing and Artificial Intelligence Journal, 2018
Smart City has an infrastructure that works with technology to reduce daily problems. The lack of parking spots is one of these problems that can be controlled by creating Smart Parking systems.
Alexis van HAARE HEIJMEIJER, Gleifer VAZ ALVES   +1 more
doaj   +1 more source

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]

PLoS ONE, 2017
BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk, Melanie C Audette, Sascha Drewlo, Khrystyna Levytska, John C Kingdom   +4 more
doaj   +1 more source

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Primary host defenses against viruses involve specific cellular recognition of non-self nucleic acids as pathogen-associated molecular patterns (PAMPs) that trigger induction of cytokine-mediated antiviral responses.
Nora Schmidt, P. Domingues, F. Golebiowski, Corinna Patzina, M. Tatham, R. Hay, B. G. Hale   +6 more
semanticscholar   +1 more source

SUMO and cellular adaptive mechanisms

Experimental and Molecular Medicine, 2020
The ubiquitin family member SUMO is a covalent regulator of proteins that functions in response to various stresses, and defects in SUMO-protein conjugation or deconjugation have been implicated in multiple diseases.
Hong-Yeoul Ryu, S. Ahn, M. Hochstrasser
semanticscholar   +1 more source

Towards efficient multiobjective optimization: multiobjective statistical criterions [PDF]

, 2012
The use of Surrogate Based Optimization (SBO) is widely spread in engineering design to reduce the number of computational expensive simulations. However, "real-world" problems often consist of multiple, conflicting objectives leading to a set of ...
Couckuyt, Ivo, Deschrijver, Dirk, Dhaene, Tom   +2 more
core   +2 more sources

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

MULTI-OBJECTIVE OPTIMIZATION OF TRAFFIC SIGNAL TIMINGS FOR MINIMIZING WAITING TIME, CO2 EMISSIONS, AND FUEL CONSUMPTION AT INTERSECTIONS

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
In this paper, we present an optimization strategy that uses Genetic Algorithms (GA) to reduce Waiting Time, CO2 Emissions, and fuel consumption in a transportation network.
Esraa Alkafaji, Husham L. Swadi
doaj   +1 more source