Results 61 to 70 of about 291,935 (374)

SUMO Chains Rule on Chromatin Occupancy

Frontiers in Cell and Developmental Biology, 2020
The dynamic and reversible post-translational modification of proteins and protein complexes with the ubiquitin-related SUMO modifier regulates a wide variety of nuclear functions, such as transcription, replication and DNA repair.
Jan Keiten-Schmitz, Kathrin Schunck, S. Müller   +2 more
semanticscholar   +1 more source

Sensitivity analysis using data-driven parametric macromodels [PDF]

, 2011
An accurate parametric macromodeling method which builds the parameterized frequency behavior of systems from frequency data samples is presented.
Chemmangat Manakkal Cheriya, Krishnan, Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc   +3 more
core   +2 more sources

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +2 more sources

Experimental Characterization of Routing Protocols in Urban Vehicular Communication

Transport and Telecommunication, 2019
Vehicular communication is a cynosure in automotive industry these days. V2V communication is one of the types of vehicular communication which render lane change warning, emergency vehicle alert, intersection alert, congestion alert, payment at tolls ...
Punia Divya, Kumar Rajender
doaj   +1 more source

Practical implementation of a sequential sampling algorithm for EMI near-field scanning [PDF]

, 2012
—In this paper, a practical implementation of a recently proposed automatic and sequential sampling algorithm for the near-field scanning of printed circuit boards and/or integrated circuits is presented.
Boesman, Bart, Couckuyt, Ivo, Deschrijver, Dirk, Dhaene, Tom, Pissoort, Davy, Van der Streek, Bram, Vanhee, Filip   +6 more
core   +2 more sources

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Primary host defenses against viruses involve specific cellular recognition of non-self nucleic acids as pathogen-associated molecular patterns (PAMPs) that trigger induction of cytokine-mediated antiviral responses.
Nora Schmidt, P. Domingues, F. Golebiowski, Corinna Patzina, M. Tatham, R. Hay, B. G. Hale   +6 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Using bioinformatics to reveal the pathogenic mechanisms of small ubiquitin-like modification in psoriasis and to predict drug sensitivity

Pifu-xingbing zhenliaoxue zazhi
[Objective] Using bioinformatics to assess the expression levels and regulatory mechanisms of small ubiquitin-related modifier (SUMO) in psoriasis, and to analyze its effect on metabolism.
YUAN Liyan, YU Xiaoling, HE Xueyu
doaj   +1 more source

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source