Dual Role of Sumoylation in the Nuclear Localization and Transcriptional Activation of NFAT1 [PDF]
, 2004 Yasuhito Terui +4 more
openalex +1 more source
Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.ISG15 is highly expressed in both DKD mice and renal tubular epithelial cell cultured in HG condition. ISG15 promotes DKD pyroptosis via NLRP3–CASP1–GSDMD axis. ISG15–mtDNA–STING emerges as a critical hub that integrates the processes of pyroptosis .
Lingzhi Huang +8 more
wiley +1 more source
Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
MedComm, Volume 6, Issue 6, June 2025.Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen +6 more
wiley +1 more source
Sumoylation of MITF and Its Related Family Members TFE3 and TFEB [PDF]
, 2004 Arlo J. Miller +4 more
openalex +1 more source
Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells
FASEB BioAdvances, Volume 7, Issue 6, June 2025.The SUV39 family members are well known for methylating the Lysine 9 of the histone H3 (H3K9) in order to compact the chromatin and contributing to gene repression. We describe their active role in proliferating and differentiating muscle stem cells, how they prevent from inflammation and fibrosis during muscle regeneration and the future avenues ...
Pauline Garcia +2 more
wiley +1 more source
Dynamin Interacts with Members of the Sumoylation Machinery [PDF]
, 2004 Ram Kumar Mishra +5 more
openalex +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.IGF2BP2 expression is enhanced by SENP1 through the regulation of SUMO1‐induced IGF2BP2 SUMOylation. Additionally, IGF2BP2 promotes the neuronal differentiation of olfactory mucosa‐mesenchymal stem cells (OM‐MSCs) by stabilizing SOX11, which helps to mitigate brain injury following intracerebral hemorrhage.
Jun He +5 more
wiley +1 more source
Identification of Xenopus heat shock transcription factor–2: conserved role of sumoylation in regulating deoxyribonucleic acid–binding activity of heat shock transcription factor–2 proteins [PDF]
, 2004 Roland S. Hilgarth +5 more
openalex +1 more source
Versatile roles of disordered transcription factor effector domains in transcriptional regulation
The FEBS Journal, Volume 292, Issue 12, Page 3014-3033, June 2025.Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta +3 more
wiley +1 more source