Results 151 to 160 of about 31,613 (261)

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications [PDF]

, 2006
Dafna Nathan, Kristin Ingvarsdottir, David E. Sterner, Gwendolyn R. Bylebyl, Milos Dokmanovic, Jean Dorsey, Kelly A. Whelan, Mihajlo L. Krsmanovic, William S. Lane, Pamela B. Meluh, Erica S. Johnson, Shelley L. Berger   +11 more
openalex   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, Volume 12, Issue 40, October 27, 2025.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation [PDF]

, 2006
Huijun Wei, Xianhui Wang, Boyi Gan, Alison M. Urvalek, Zara Melkoumian, Jun-Lin Guan, Jihe Zhao   +6 more
openalex   +1 more source

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Ubiquitin‐mediated selective autophagy plays a critical role in antiviral innate immunity. The study shows that upon RNA virus infection, cytoplasmic API5 undergoes SRPK1‐dependent phosphorylation at S464, which in turn suppresses p62 K141 ubiquitination‐dependent autophagy.
Tingjuan Deng, Jianan Xu, Linglong Qin, Xingbo Wang, Chenhe Lu, Yanming Huang, Da Liu, Yan Yan, Weiren Dong, Pinglong Xu, Jiyong Zhou   +10 more
wiley   +1 more source

PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G₁ and G₂ by Sumoylation of p73

, 2004
Eliana Munarriz, Daniela Barcaroli, Anastasis Stephanou, Paul A. Townsend, Carine Maisse, Alessandro Terrinoni, Michael H. Neale, Séamus J. Martin, David S. Latchman, Richard A. Knight, Gerry Melino, Vincenzo De Laurenzi   +11 more
openalex   +1 more source

Sumoylation and desumoylation assays for a chromatin-remodelling complex in vivo and in vitro [PDF]

, 2006
Jung Hwa Kim, Keun Il Kim, Sung Hee Baek
openalex   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ [PDF]

, 2007
Serena Ghisletti, Wendy Huang, Sumito Ogawa, Gabriel Pascual, Mu-En Lin, Timothy M. Willson, Michael G. Rosenfeld, Christopher K. Glass   +7 more
openalex   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: A proteomic analysis

, 2004
Tianwei Li, Evgenij Evdokimov, Rong‐Fong Shen, Chien‐Chung Chao, Ephrem Tekle, Tao Wang, Earl R. Stadtman, David C.H. Yang, P Boon Chock   +8 more
openalex   +1 more source