Results 201 to 210 of about 35,698 (247)

Deciphering the Ubiquitin-like Code of DNA-PK: Mechanisms and Therapeutic Opportunities. [PDF]

Biomolecules
Zhao J, Qin Z, Hou J, Lu M, Guo J, Wu J, Wang C, Zhu X, Ma T.   +8 more
europepmc   +1 more source

The evolution of azole resistance through a reduced spore dormancy pathway associated with loss of SUMOylation function in <i>Fusarium graminearum</i>. [PDF]

Appl Environ Microbiol
Wog K, Sumanarathne AS, Gerstein AC, Bakker MG.   +3 more
europepmc   +1 more source

Machine Learning-Based Integrative Analysis Identifies SUMOylation-Related Genes Underlying the Immune Heterogeneity of Sepsis. [PDF]

IET Syst Biol
Li Z, Yang J, Dong J, Ye Z, Li C, Hu Y, Ren H, Li S, Ji Z.   +8 more
europepmc   +1 more source

Pathogen-induced hijacking of host SUMOylation: from molecular mechanisms and prospects for therapeutic modulation. [PDF]

Front Immunol
Padmakumar S, Madhavan A, Nair BG, Kumar GB.   +3 more
europepmc   +1 more source

UBE2I promotes immune infiltration and tumor progression in thyroid cancer and modulates hnRNPA2B1 SUMOylation. [PDF]

J Biol Chem
Wang J, Qiu M, Dong L, Hao J, Gao Y, Tao W, Wang S, Duan R, Gao M.   +8 more
europepmc   +1 more source

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SUMOylation in atherosclerosis

Clinica Chimica Acta, 2020
Atherosclerosis (AS) is the pathophysiologic basis of many cardiovascular diseases. A number of studies have shown that post-translational modification (PTM) contributes to the initiation and progression of AS. For example, recent studies found that SUMOylation, ie, small ubiquitin-like modifier (SUMO) conjugation to target substrate proteins, was ...
Yi-Zhang Liu, Xuan Xiao, Chu-Ting Hu, Yuan Dai, Shun-Lin Qu, Liang Huang, Chi Zhang   +6 more
openaire   +2 more sources

Pc2 and SUMOylation

Biochemical Society Transactions, 2007
Polycomb proteins are key regulators of transcription in metazoan organisms. Recent work has shed light on the nature of the polycomb protein complexes in flies and mammalian cells. Multiple enzymatic activities have been shown to associate with polycomb complexes, including histone methyltransferase, histone deacetylase and ubiquitination activities ...
D, Wotton, J C, Merrill
openaire   +2 more sources

SUMOylation in carcinogenesis

Cancer Letters, 2012
SUMOylation is a post-translational modification characterized by covalent and reversible binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different isoforms, termed SUMO-1, -2, -3 and -4 have been identified so far.
Bettermann, Kira; Benesch, Martin; Weis, Serge; Haybaeck, Johannes   +4 more
openaire   +2 more sources

Targeting SUMOylation in cancer

Current Opinion in Oncology, 2021
Purpose of review In the article, we focus on the role of SUMOylation in tumorigenesis and cancer-related processes, including Epithelial–mesenchymal transition (EMT), metastasis, resistance to cancer therapies, and antitumor immunity. Clinical perspective on small ubiquitin-like modifier (SUMO) inhibitors will be discussed.
Li, Du, Wei, Liu, Steven T, Rosen
openaire   +2 more sources

Uncovering global SUMOylation signaling networks in a site-specific manner

Nature Structural and Molecular Biology, 2014
SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution MS, we have studied global SUMOylation in human cells in a site-specific manner, identifying a total of >4,300 SUMOylation sites in >1,600 ...
Ivo A Hendriks, Matthias Mann, Alfred C O Vertegaal   +2 more
exaly   +2 more sources