Results 51 to 60 of about 546 (232)

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source

Low-latitude Sunspot Group Tilt Angles in 15–24 Activity Cycles

The Astrophysical Journal
An analysis of the tilt angles of the active regions in 15–24 activity cycles was performed. We used data from measurements of magnetic fields in the sunspot umbra in the period 1918–2019 at the Mount Wilson Observatory, as well as the tilt angles of ...
Andrey G. Tlatov
doaj   +1 more source

Distracted by a plant: movement of two invasive pentatomids, Halyomorpha halys and Nezara viridula, between companion plants and berry crops

Pest Management Science, EarlyView.
Adult Halyomorpha halys and Nezara viridula rapidly moved between berry crops and companion plants. Habitat use varied across environmental contexts, demonstrating that companion plantings function as dynamic elements in diversified cropping systems. Abstract BACKGROUND The brown marmorated stink bug Halyomorpha halys and the southern green stink bug ...
Sophie Wenz, Nathalie Ramlow, Christine Becker, Annette Reineke   +3 more
wiley   +1 more source

HSPE1 deficiency underlies the crosstalk between metabolic dysfunction‐associated steatotic liver disease and age‐related macular degeneration

VIEW, EarlyView.
Rare‐earth ions act as multifunctional modifiers in perovskite solar cells by improving charge transport, suppressing oxygen vacancies, passivating defects, promoting grain growth, and enabling redox‐mediated stabilization. In addition, RE‐doped layers can expand spectral utilization through upconversion and downconversion, thereby enhancing light ...
Jiaqi Meng, Alimire Maihemuti, Yuan Yuan, Chao Chen, Mengchao Zhu, Hao Wang, Furong Zhu, Zhaodi Che, Jia Xiao, Xiangjia Zhu   +9 more
wiley   +1 more source

Understanding Solar Activity after the Maunder Minimum: Sunspot Records by Rost and Alischer

The Astrophysical Journal
The Maunder Minimum was a period with significantly reduced solar activity between 1645 and 1715, approximately. The transition between the low solar activity in the Maunder Minimum and the subsequent “normal” regime of solar activity was gradual ...
V. M. S. Carrasco, A. J. P. Aparicio, T. Chatzistergos, S. Jamali Jaghdani, H. Hayakawa, M. C. Gallego, J. M. Vaquero   +6 more
doaj   +1 more source

Unveiling Otolith Mystery: Contemporary Testing Approaches and Their Clinical Significance

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Otolith is a critical component of the peripheral vestibular system responsible for detecting linear acceleration. Dysfunction of the otolith organs can lead to vertigo, balance disturbances, and gaze instability. By elucidating the physiological foundations and evaluating both current and emerging methods for assessing otolith ...
Shun Zhou, E Tian, Hua‐Jing Yang, Jun Wang, Zhao‐Qi Guo, Jing‐Yu Chen, Wan‐Di Xu, Jia‐Qi Guo, Zhang‐Hong Zhou, Shi‐Yu Shi, Xi‐Xi Yu, Xin‐Bo Gao, Ni Zhai, Xin Ma, Qing Zhang, Yi‐Sheng Lu, Su‐Lin Zhang   +16 more
wiley   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

The impacts of high refractive errors on self‐reported visual function and visual concern

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine the association between refractive errors and self‐reported visual function and visual concern, considering self‐perceived present eyesight, concerns about vision, accomplishing less and limitations in daily activities in an eye‐healthy cohort.
Jens Riis Møller, Arevak Saruhanian, Jens Rovelt, Josefine Freiberg, Marcel Reimann, Jeppe Nygård Samuelsen, Christina Eckmann‐Hansen, Miriam Kolko, Nina Jacobsen, FOREVER Consortium   +9 more
wiley   +1 more source

Three hundred sixty‐degree prophylactic laser retinopexy versus focal laser during rhegmatogenous retinal detachment repair: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To compare the anatomic, functional and safety outcomes of intra‐operative 360‐degree prophylactic laser retinopexy versus focal laser retinopexy during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) and to assess the certainty of evidence.
Luke Yaldo, Albert Ting, Saif Pasha, Kyle Sporn, Abdelaziz Abdelaal, Joshua Ong   +5 more
wiley   +1 more source