Results 171 to 180 of about 12,609 (207)
Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence
EMBO Journal, 2001 The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA-DR1) has been determined by X-ray crystallography to 2.6 Å resolution (1HXY).
Göran Forsberg +2 more
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Cell Biophysics, 1993
The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on MHC class II antigens. In order to induce T lymphocytes to reject a tumor, we substituted the specificity of SEA for MHC class II molecules with specificity for tumor cells by combining SEA with a MAb recognizing colon ...
T, Kalland +8 more
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The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on MHC class II antigens. In order to induce T lymphocytes to reject a tumor, we substituted the specificity of SEA for MHC class II molecules with specificity for tumor cells by combining SEA with a MAb recognizing colon ...
T, Kalland +8 more
openaire +2 more sources
Journal of the American Academy of Dermatology, 2011
Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs.
Edgar S, Macias +3 more
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Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs.
Edgar S, Macias +3 more
openaire +2 more sources
Immunological Investigations, 1997
Superantigens comprise a large group of viral and bacterial proteins that stimulate T lymphocyte proliferation without regard for the antigenic specificity of the T cells but dependent on the composition of the variable part of the beta chain of the T cell receptor.
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Superantigens comprise a large group of viral and bacterial proteins that stimulate T lymphocyte proliferation without regard for the antigenic specificity of the T cells but dependent on the composition of the variable part of the beta chain of the T cell receptor.
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2007
Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. They activate the immune system by binding to the major histocompatibility complex (MHC) class II and T cell receptor molecules. One of the major producers of SAgs is Streptococcus pyogenes, or group A streptococcus (GAS).
Thomas, Proft, John D, Fraser
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Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. They activate the immune system by binding to the major histocompatibility complex (MHC) class II and T cell receptor molecules. One of the major producers of SAgs is Streptococcus pyogenes, or group A streptococcus (GAS).
Thomas, Proft, John D, Fraser
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Current Opinion in Structural Biology, 1995
Bacterial superantigens are extremely potent activators of the immune system. Their ability to efficiently cross-link molecules of the major histocompatibility complex class II and T-cell receptors causes the normal antigen specificity of each receptor to be bypassed.
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Bacterial superantigens are extremely potent activators of the immune system. Their ability to efficiently cross-link molecules of the major histocompatibility complex class II and T-cell receptors causes the normal antigen specificity of each receptor to be bypassed.
openaire +2 more sources
Superantigens: Supersignalers?
Science's STKE, 2006Some bacterial and viral proteins are potent activators of the immune response, earning them the title of superantigens (SAgs). Infection with pathogens containing these proteins can produce massive T cell activation and can result in various potentially fatal conditions, such as toxic shock and food poisoning.
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2003
This chapter describes a quantitative assay for the streptococcal superantigen, streptococcal pyrogenic exotoxin A (SPEA), which can be used in broth, tissue-culture media, and certain sera. The protocol can be adapted to allow measurement of any bacterial superantigen or protein toxin, using different oligonucleotides to amplify the coding sequences ...
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This chapter describes a quantitative assay for the streptococcal superantigen, streptococcal pyrogenic exotoxin A (SPEA), which can be used in broth, tissue-culture media, and certain sera. The protocol can be adapted to allow measurement of any bacterial superantigen or protein toxin, using different oligonucleotides to amplify the coding sequences ...
openaire +2 more sources