Results 11 to 20 of about 315,385 (314)
Superoxide dismutase in leukocytes [PDF]
FEBS Letters, 1974 1 ] or NBT [ 141 in the xanthine-xanthine oxidase reaction. The reduction of NBT and cytochrome c was followed at 560 and 550 nm respectively. One unit of SOD activity is defined as the amount of enzyme that causes a decrease of the optical density from 0.025 to 0.0125 in 1 min using 1 cm light path cuvette.
Pierluigi Patriarca +2 more
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Scavenging of superoxide by a membrane-bound superoxide oxidase [PDF]
Nature Chemical Biology, 2018 Superoxide is a reactive oxygen species produced during aerobic metabolism in mitochondria and prokaryotes. It causes damage to lipids, proteins and DNA and is implicated in cancer, cardiovascular disease, neurodegenerative disorders and aging. As protection, cells express soluble superoxide dismutases, disproportionating superoxide to oxygen and ...
Lundgren, Camilla A K +9 more
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Superoxide Dismutases and Superoxide Reductases
Chemical Reviews, 2014 Superoxide, O2•–, is formed in all living organisms that come in contact with air, and, depending upon its biological context, it may act as a signaling agent, a toxic species, or a harmless intermediate that decomposes spontaneously. Its levels are limited in vivo by two different types of enzymes, superoxide reductase (SOR) and superoxide dismutase ...
Isabel A. Abreu +7 more
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Siberian Journal of Life Sciences and Agriculture, 2022 Background. The mitochondrial electron transport chain, in particular the respiratory complex I, is one of the main sources of reactive oxygen species (ROS) in living cells. Suppression of the complex I activity in human cells through chemical inhibition
Vladislav I. Tarasenko +3 more
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Molecules, 2014 Iron is an essential co-factor for many enzymes that catalyze electron transfer reactions. It is well known that so-called “poorly liganded” iron can increase ROS concentrations and trigger oxidative stress that is capable of initiating apoptosis ...
Vladimir Chobot +2 more
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Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes
Biomedicines, 2023 Chronic kidney disease (CKD) predisposes one toward end-stage renal disease (ESRD) and its associated morbidity and mortality. Significant metabolic perturbations in conjunction with alterations in redox status during CKD may induce increased production ...
Kranti A. Mapuskar +5 more
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Chemosensors, 2021 Oxygen and nitrogen free radicals (RONS) form an exceptionally reactive molecular assembly within eukaryote cells. This perspective article gives a combined overview of different facets of research covering molecular reactivity, resultant tissue damage ...
Pankaj Vadgama
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Copper- and Zinc-containing Superoxide Dismutase Can Act as a Superoxide Reductase and a Superoxide Oxidase [PDF]
Journal of Biological Chemistry, 2000 The copper- and zinc-containing superoxide dismutase can catalyze the oxidation of ferrocyanide by O(2) as well as the reduction of ferricyanide by O(2). Thus, it can act as a superoxide dismutase (SOD), a superoxide reductase (SOR), and a superoxide oxidase (SOO).
Stefan I. Liochev, Irwin Fridovich
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Molecules, 2021 The superoxide radical ion is involved in numerous physiological processes, associated with both health and pathology. Its participation in cancer onset and progression is well documented.
Lozan Todorov +5 more
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Molecules, 2021 The mechanism behind the cytoprotective potential of cerium oxide nanoparticles (CeO2 NPs) against cytotoxic nitric oxide (NO) donors and H2O2 is still not clear.
Mohd Javed Akhtar +2 more
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