Results 221 to 230 of about 533,516 (306)

Sulfur Bridge Geometry Boosts Selective FeIV═O Generation for Efficient Fenton‐Like Reactions

open access: yesAdvanced Science, EarlyView.
The sulfur bridge regulated the geometry and electronic effects of Fe diatomic pairs for selective and efficient generation of FeIV═O, opening an avenue to tune the microenvironment of active atomically dispersed sites and increase their loading amounts. Abstract High‐valent iron–oxo species (FeIV═O) is a fascinating enzymatic agent with excellent anti‐
Xunheng Jiang   +12 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

open access: yesAdvanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua   +19 more
wiley   +1 more source

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren   +6 more
wiley   +1 more source

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan   +7 more
wiley   +1 more source

Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement
Ercan H   +10 more
europepmc   +1 more source

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