Results 131 to 140 of about 402,173 (377)

Superoxide dismutase activity of low molecular weight Cu²⁺‐chelates studied by pulse radiolysis [PDF]

, 1974
Regina Brigelius, Rita Spöttl, Wolf Bors, Edmund Lengfelder, Manfred Sarán, Ulrich Weser   +5 more
openalex   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Colostrum-Derived Melatonin Plus PEG Microspheres Modulate the Oxidative Metabolism of Human Colostrum Phagocytes

Metabolites
Background/Objectives: Exogenous melatonin adsorbed onto PEG microspheres can modulate the functional activity of phagocytes in colostrum, but no data are available on the activity of melatonin found in colostrum.
Caroline G. Silva, Viviane F. Luz, Victor L. Nunes, Ana B. M. Verzoto, Aron C. de M. Cotrim, Wagner B. dos Santos, Eduardo L. França, Adenilda C. Honorio-França   +7 more
doaj   +1 more source

Superoxide Dismutases of Escherichia coli : Intracellular Localization and Functions [PDF]

, 1973
Eugene M. Gregory, Fred J. Yost, Irwin Fridovich   +2 more
openalex   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Identification of iron(III) peroxo species in the active site of the superoxide reductase SOR from Desulfoarculus baarsii [PDF]

Journal of the American Chemical Society, American Chemical Society, 2002, pp.4966-7, 2015
The active site of superoxide reductase SOR consists of an Fe2+ center in an unusual [His4 Cys1] square-pyramidal geometry. It specifically reduces superoxide to produce H2O2. Here, we have reacted the SOR from Desulfoarculus baarsii directly with H2O2.
arxiv  

A pulse-radiolysis study of the manganese-containing superoxide dismutase from Bacillus stearothermophilus. A kinetic model for the enzyme action [PDF]

, 1977
Michael E. McAdam, R A Fox, François Lavelle, E.M. Fielden   +3 more
openalex   +1 more source

Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

Advanced Science, EarlyView.
A tumor‐targeted, renal‐metabolized, and less O2‐dependent Type‐I photosensitizer is presented for photodynamic therapy of tumors. The formation of an intramolecular sandwich‐like π–π assembly ensures its rigid orthogonal geometry, thereby improving the superoxide (O2•−)‐generating ability, promoting the intracellular formation of hydroxy radical (HO•),
Guangxiao Yao, Junfeng Miao, Yingying Huo, Wei Guo   +3 more
wiley   +1 more source

Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy

Advanced Science, EarlyView.
This study develops a cancer cell membrane‐coated nanozyme that enhances radiotherapy and reshapes the immunosuppressive microenvironment by generating oxygen in situ and disrupting tumor antioxidant defenses, offering a new strategy for breast cancer radioimmunotherapy.
Kun Qiao, Yongbiao Huang, Shipeng Ning, Meng Lyu, Jieqiong Xie, Shiyuan Zhang, Xiuxin Lu, Yuan Yu, Wei Jiang, Bo Liu, Kelong Fan, Tong Liu   +11 more
wiley   +1 more source

Superoxide dismutase and glutathione peroxidase activities in tumors [PDF]

, 1977
Alexander V. Peskin, Ya. M. Koen, I.B. Zbarsky   +2 more
openalex   +1 more source