DFT Investigation of Biocatalytic Mechanisms from pH-Driven, Multi-Enzyme, Biomimetic Behavior in CeO2 [PDF]
There is considerable interest in the pH-dependent, switchable, biocatalytic properties of cerium oxide (CeO2) nanoparticles (CeNPs) in biomedicine, where these materials exhibit beneficial antioxidant activity against reactive oxygen species (ROS) at basic physiological pH but cytotoxic prooxidant activity in acidic cancer cell pH microenvironment ...
arxiv +1 more source
The trail to superoxide dismutase [PDF]
City College of New York + Cornell Medical School + Duke. While a youngster, I was enthralled by the miracle of insect metamorphosis and followed the transformations of pet caterpillars to pupae and then to gloriously beautiful butterflies and moths. This led naturally to an interest in biology. but mere description was not totally satisfying.
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Enterocyte superoxide dismutase 2 deletion drives obesity
Summary: Compelling evidence support an involvement of oxidative stress and intestinal inflammation as early events in the predisposition and development of obesity and its related comorbidities.
Oihane Garcia-Irigoyen+18 more
doaj
OBJECTIVES: Our previous study demonstrated that superoxide dismutase levels were higher in tuberculous pleural effusions than in malignant pleural effusions, but that this difference ...
Maoshui Wang+2 more
doaj +1 more source
Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19 [PDF]
There is no vaccine or specific antiviral treatment for COVID-19. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown. It is therefore challenging to discover a successful treatment to be approved for clinical use.
arxiv +1 more source
Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer
Background: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast ...
Fezzeh Elyasinia+4 more
doaj +1 more source
Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma [PDF]
Background: A rapid increase in the turnover of malignant cells modulates the enzymes level in circulation and may be a prognostic sign of disease progression.
Bogdanović Gordana+9 more
doaj +1 more source
High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis [PDF]
Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cytokines by DCs.
arxiv +1 more source
Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis [PDF]
Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease, causing motor neuron degeneration, muscle atrophy, paralysis, and death. Despite this degenerative process, a stable hypermetabolic state has been observed in a large subset of patients.
arxiv +1 more source
Superoxide dismutase in anaerobes: survey [PDF]
Superoxide dismutase (SOD) was present in 23 of 28 strains of the genus Bacteroides tested. Several clostridia, anaerobic cocci, and anaerobic, grampositive, nonsporing rods contained measureable SOD, but the frequency of SOD occurrence was much lower than in the bacteroides.
W E Moore, L V Holdeman, E M Gregory
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