Results 201 to 210 of about 9,691 (244)
The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways. [PDF]
J Oral Pathol MedChan LP +9 more
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Pulmonary Pharmacology & Therapeutics, 2002
In this review we describe the potential role(s) of superoxide in inflammatory disorders.
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In this review we describe the potential role(s) of superoxide in inflammatory disorders.
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Superoxide, Superoxide Dismutase and the Respiratory Burst
Veterinary Clinical Pathology, 1983SummaryPhagocytes undergo a sharp burst of oxygen consumption when engulfing bacteria. This oxygen is enzymatically reduced to toxic metabolites which are essential to the bactericidal action of the cell. Oxygen metabolites formed in this burst as well as other intermediates formed in biological reduction reactions do not selectively reserve their ...
H S, Bender, W R, Chickering
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SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES
Annual Review of Biochemistry, 1972O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH ...
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Engineered Superoxide Dismutase Monomers for Superoxide Biosensor Applications
Analytical Chemistry, 2005Because of its high reaction rate and specificity, the enzyme superoxide dismutase (SOD) offers great potential for the sensitive quantification of superoxide radicals in electrochemical biosensors. In this work, monomeric mutants of human Cu,Zn-SOD were engineered to contain one or two additional cysteine residues, which could be used to bind the ...
Beissenhirtz, Moritz Karl +3 more
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Parasitology Today, 1994
Eric James here discusses the molecular forms of superoxide dismutase and looks at its potential role in the pathogenesis of parasitic infections.
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Eric James here discusses the molecular forms of superoxide dismutase and looks at its potential role in the pathogenesis of parasitic infections.
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Extracellular superoxide dismutase
The International Journal of Biochemistry & Cell Biology, 2005The extracellular space is protected from oxidant stress by the antioxidant enzyme extracellular superoxide dismutase (EC-SOD), which is highly expressed in selected tissues including blood vessels, heart, lungs, kidney and placenta. EC-SOD contains a unique heparin-binding domain at its carboxy-terminus that establishes localization to the ...
Eva, Nozik-Grayck +2 more
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Keratinocyte Superoxide Generation
Free Radical Biology and Medicine, 1998We have demonstrated using the reduction of cytochrome c, that the keratinocyte cell line H357 generates superoxide at significant rates (8.36 nmol/h/10[6] cells). The rate of superoxide release decreased as the cells reached confluence. Superoxide production was increased more than twofold following preincubation with IL-1beta, or by the addition of ...
Turner, CP, Toye, AM, Jones, OTG
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