Results 211 to 220 of about 9,691 (244)

Theoretical Studies of Manganese and Iron Superoxide Dismutases:  Superoxide Binding and Superoxide Oxidation

The Journal of Physical Chemistry B, 2005
Density-functional calculations indicate that the second sphere of coordination around the metal centers of manganese and iron superoxide dismutases (MnSODs and FeSODs) plays an important role in the binding of O2(-). In these systems, O2(-) prefers to bind to Mn or Fe in end-on configurations. For human and E.
Isabel A, Abreu, José A, Rodriguez, Diane E, Cabelli   +2 more
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Superoxide, superoxide dismutase and ischemic injury.

Current opinion in investigational drugs (London, England : 2000), 2002
Oxidative stress results from an oxidant/antioxidant imbalance: an excess of oxidants relative to the antioxidant capacity. Recent evidence strongly suggests that oxidant stress plays a major role in several aspects of ischemia and reperfusion. Immunohistochemical and biochemical evidence demonstrate the significant role of reactive oxygen species, in ...
Salvemini, Daniela, CUZZOCREA, Salvatore
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Superoxidation of Retinoic Acid

Photochemistry and Photobiology, 2006
Atmospheric pressure chemical ionization mass spectroscopy (APCI-MS) was used to examine the light-induced oxidation products of retinoic acid under conditions that favor and preclude its aggregation. We observed that in conditions that favor aggregation, i.e. in aqueous solutions, retinoic acid undergoes superoxidation to yield highly oxidized species.
Ilyas, Washington, Nicholas J, Turro, Koji, Nakanishi   +2 more
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Superoxide Dismutases: Defence Against Endogenous Superoxide Radical

2008
Attempts to measure the rate of O2- production, in whole cells or in intact subcellular organelles, are frustrated by the endogenous superoxide dismutase (SOD). Streptococcus faecalis contains a single manganese-SOD which was isolated and used as an antigen in the rabbit. A precipitating and inhibiting antibody was obtained and used to suppress the SOD
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Superoxide Dismutase Biosensors for Superoxide Radical Analysis

Analytical Letters, 1999
ABSTRACT Some basic work has been performed on the development and optimisation of superoxide dismutase (SOD) biosensors for superoxide radical analysis. Initially we studied the possibility of obtaining a SOD biosensor using the Clark electrode as indicating sensor.
CAMPANELLA, Luigi, FAVERO, Gabriele, TOMASSETTI, Mauro   +2 more
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A superoxide dismutase-modified electrode that detects superoxide ion

Chemical Communications, 2002
A superoxide dismutase (SOD)-modified electrode, in which SOD is oriented on the gold electrode via a self-assembled monolayer of cysteine so as to allow its direct electrode reaction, possesses a bi-directional electrocatalysis for both the oxidation of superoxide ion (O2-) to O2 and the reduction of O2- to H2O2 and functions as a third generation O2-
T.Ohsaka, Y.Tian, M.Shioda, S.Kasahara, T.Okajima   +4 more
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Microplate Superoxide Dismutase Assay Employing a Nonenzymatic Superoxide Generator

Analytical Biochemistry, 1995
The antioxidant enzyme superoxide dismutase (EC 1.15.1.1) (SOD) catalyzes the conversion of superoxide anion radical (O2.-) to hydrogen peroxide and molecular oxygen. SOD helps prevent tissue damage by O2.- and its metabolites, and augmentation of tissue SOD is a useful therapeutic strategy in certain diseases having an oxidative-injury component ...
J F, Ewing, D R, Janero
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Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

Nature, 1983
Electrostatic forces have been implicated in a variety of biologically important molecular interactions including drug orientation by DNA, protein folding and assembly, substrate binding and catalysis and macromolecular complementarity with inhibitors, drugs and hormones.
E D, Getzoff, J A, Tainer, P K, Weiner, P A, Kollman, J S, Richardson, D C, Richardson   +5 more
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Superoxide Radical and Superoxide Dismutases: Threat and Defense

1980
An enzymic flux of O2- and H2O2 caused strand breaks in the supercoiled covalently closed circular Col El plasmid. Subnanomolar levels of superoxide levels of superoxide dismutase or of catalase prevented this attack on DNA, signifying that both O2- and H2O2 were required.
K, Brawn, I, Fridovich
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Superoxide-Superoxide Oxidoreductase Activity of the Captopril-Copper Complex

Archives of Medical Research, 2002
The purpose of this study was to determine whether the interaction of captopril, an angiotensin-converting enzyme inhibitor, with copper could modify the superoxide dismutase activity of this metal. Results may help to explain the interaction of captopril with reactive oxygen species in the stunned myocardium where substantial mobilization of copper ...
David, Jay, Elizabeth J, García, María del Carmen, Avila, Eduardo, Muñoz, Roberto, Gleason   +4 more
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