Results 41 to 50 of about 248,641 (339)

Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery

Journal of Oral Microbiology
Background Gingipains are important virulence factors present in Porphyromonas gingivalis. Arginine-specific gingipains (RgpA and RgpB) are critically associated with increased proteolytic activity and immune system dysfunction, including neutrophilic ...
Vanessa Tubero Euzebio Alves, Tomaz Alves, Emanuel Silva Rovai, Hatice Hasturk, Thomas Van Dyke, Marinella Holzhausen, Alpdogan Kantarci   +6 more
doaj   +1 more source

Nitrate Increases Aluminum Toxicity and Accumulation in Root of Wheat

Agriculture, 2022
Aluminum (Al) toxicity inhibits root growth, while nitrogen is an essential nutrient for plant growth and development. To explore the effects of nitrate (N) on Al toxicity and accumulation in root of wheat, two wheat genotypes, Shengxuan 6 hao (SX6, Al ...
Yan Ma, Caihong Bai, Xincheng Zhang, Yanfeng Ding   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Extracellular superoxide dismutase VdSOD5 is required for virulence in Verticillium dahliae

Journal of Integrative Agriculture, 2021
Plants produce reactive oxygen species (ROS) to defend pathogens. To counteract this attack, certain pathogens express superoxide dismutases (SODs) to scavenge host-derived ROS.
Li TIAN, Cai-min HUANG, Dan-dan ZHANG, Ran LI, Jie-yin CHEN, Wei-xia SUN, Nian-wei QIU, Xiao-feng DAI   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Impact of Some Immunological Parameters (antioxidant – cytokines) in Cutaneous leishmaniasis in a Sample of Patients in the Al-Ramadi City.

مجلة مركز بحوث التقنيات الاحيائية
Background: Cutaneous leishmaniasis is one of the endemic diseases in Iraq. Both types of cutaneous leishmaniasis that cause different ulcers are present, namely Leishmania major and Leishmania tropica, The disease also represents a major public and ...
Othman M. Mohammad, Thaer A. Salih, Mohammad M. Al-Halbosiy   +2 more
doaj   +1 more source

Deactivation of the JNK Pathway by GSTP1 Is Essential to Maintain Sperm Functionality

Frontiers in Cell and Developmental Biology, 2021
Fifty percent of male subfertility diagnosis is idiopathic and is usually associated with genetic abnormalities or protein dysfunction, which are not detectable through the conventional spermiogram.
Marc Llavanera, Marc Llavanera, Yentel Mateo-Otero, Yentel Mateo-Otero, Ariadna Delgado-Bermúdez, Ariadna Delgado-Bermúdez, Sandra Recuero, Sandra Recuero, Samuel Olives, Samuel Olives, Isabel Barranco, Isabel Barranco, Marc Yeste, Marc Yeste   +13 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Cellular Antioxidant Effects and Bioavailability of Food Supplements Rich in Hydroxytyrosol

Applied Sciences, 2021
The present study evaluates the effect of olive (Olea europaea L.) vegetation water on human cells regarding its antioxidant properties and radical scavenger bioactivities.
Cecilia Bender, Sarah Straßmann, Pola Heidrich   +2 more
doaj   +1 more source