Results 41 to 50 of about 10,484 (294)

Spin-Orbital Ordering in Alkali Superoxides [PDF]

Akali superoxides AO2 (A=Na, K, Rb, Cs), due to an open p shell of the oxygen ion O2^- with degenerate pi orbitals, have spin and orbital degrees of freedom.
Naka, Makoto, Shibata, Kohei, Otsuki, Junya, Jeschke, Harald O.   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Thermo-analytical Investigations on the Superoxides AO₂ (A = K, Rb, Cs), Revealing Facile Access to Sesquioxides A₄O₆

, 2017
Rb4O6 and Cs4O6 represent open shell p electron systems, featuring charge, spin, orbital and structural degrees of freedom, which makes them unique candidates for studying the ordering processes related, otherwise exclusively encountered in transition ...
Merz, P., Felser, C., Jansen, M., Schmidt, M.   +3 more
core   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis

Biomedicines
Background: In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations in diabetic peripheral neuropathy (DN).
Islauddin Khan, Sukhmandeep Kaur, Arun K. Rishi, Breana Boire, Mounika Aare, Mandip Singh   +5 more
doaj   +1 more source

Deactivation of the JNK Pathway by GSTP1 Is Essential to Maintain Sperm Functionality

Frontiers in Cell and Developmental Biology, 2021
Fifty percent of male subfertility diagnosis is idiopathic and is usually associated with genetic abnormalities or protein dysfunction, which are not detectable through the conventional spermiogram.
Marc Llavanera, Marc Llavanera, Yentel Mateo-Otero, Yentel Mateo-Otero, Ariadna Delgado-Bermúdez, Ariadna Delgado-Bermúdez, Sandra Recuero, Sandra Recuero, Samuel Olives, Samuel Olives, Isabel Barranco, Isabel Barranco, Marc Yeste, Marc Yeste   +13 more
doaj   +1 more source

Angiopoietin-1 Reduces H2O2-Induced Increases in Reactive Oxygen Species and Oxidative Damage to Skin Cells [PDF]

, 2010
UV light–based damage to skin cells can cause photoaging and skin cancer. A major cause of UV light–induced damage to skin is increased free radicals, such as superoxides. Increased superoxides can cause oxidative and nitrative damage to cell components.
Shih, Shou-Ching, Li, Dan, Ismail, Nesreen S., Dallabrida, Susan M., Pravda, Elke A.   +4 more
core   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Cellular Antioxidant Effects and Bioavailability of Food Supplements Rich in Hydroxytyrosol

Applied Sciences, 2021
The present study evaluates the effect of olive (Olea europaea L.) vegetation water on human cells regarding its antioxidant properties and radical scavenger bioactivities.
Cecilia Bender, Sarah Straßmann, Pola Heidrich   +2 more
doaj   +1 more source