Results 101 to 110 of about 7,868,657 (294)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Effects of Perceived Supervisor Support and Servant Leadership on Voluntary Turnover

Humaniora, 2019
This research aimed to investigate the predictive validity of perceived supervisor support and servant leadership on voluntary turnover. Data were taken from employees and ex-employees of five batches of the development program in a company in Jakarta ...
Debora Eflina Purba, Ahmad Raldiano Fawzi   +1 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rethinking employee retention: Mediating effect of organizational support and moderating effect of transformational leadership

Social Sciences and Humanities Open
Employee retention remains a major challenge for labor-intensive industries, particularly Bangladesh's Ready-Made Garment (RMG) sector. Where high workforce turnover disrupts organizational performance.
Atiqur Rahaman, Md Obaidul Hoque, Md Mosharraf Hossain, Mohammed Mahin Uddin, Zahurul Alam, Mahin Jamal, Farha Sultana, Md Alamgir Hossan   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The prediction power of job involvement by perceived support of supervisor and coworkers

بهداشت و ایمنی کار, 2013
Introduction: Researches show that workplace quality play important role in developing job involvement. The purpose of this study was to determine the predicted power of job involvement by perceived supervisor support and perceived coworker support ...
F. kiani, M. R. Khodabakhsh
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

SUPERVISOR COMMUNICATION IN TRAINING PROGRAM: AN EMPIRICAL STUDY IN MALAYSIA [PDF]

A thorough review of human resource development literature shows that the ability of supervisors to use good communication styles in managing programs will invoke employees’ motivation to learn, this may lead to increased positive individual attitudes ...
Sheela Chitra Chandra SEGARAN, Azman ISMAIL, Rabaah TUDIN, Sofiah BONGOGOH, Rodney Gavin   +4 more
core  

Optimizer Algorithms for Supervisory Control : Enabling Supervisor Input:(SUPEROPT D2) [PDF]

, 2012
This document reports the methods developed by the SUPEROPT project for supervisor interaction with optimizers. Two mathematical forms for an optimizer to support a Multi-Sector Controller are presented and compared, including various constraint forms to
Richards, Arthur G, Turnbull, Oliver D N
core