Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The International PhD student journey
Realising the growing diversity of post graduate researchers in the UK, this article aims at shedding light on the complexities of the research journey for international students by analysing and interpreting the cultural assumptions embedded in the PhD ...
Osman, Hanaa
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The Relationships among Proactive Personality, Work Engagement, and Perceived Work Competence in Sports Coaches: The Moderating Role of Perceived Supervisor Support. [PDF]
Int J Environ Res Public Health, 2022 Lin SH, Lu WC, Chen YC, Wu MH.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Who stay unwillingly in a job?
The paper examines the antecedents of intentions to quit, job search, and actual job switches during a five-year follow-up period. We use a representative random sample of all Finnish employees (N = 2800).
Böckerman, Petri +3 more
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AN INVESTIGATIONAL RESEARCH ON THE CORRELATION BETWEEN THE MANAGER‘S ROLE IN TRAINING PROGRAMS AND TRAINING TRANSFER IN A LOCAL GOVERNMENT OFFICE IN MALAYSIA [PDF]
This research was designed to investigate the correlation between manager‘s role andtraining transfer. A survey method was employed to gather 427 usable questionnaires fromgovernment servants in a local government office in Malaysia.
Hamid Norashikin Sahol +3 more
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Strengthening supervisor support for employees with common mental health problems: developing a workplace intervention using intervention mapping. [PDF]
BMC Public Health, 2022 van Hees SGM +3 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Malaysian School Counselor's Self-Efficacy: The Key Roles of Supervisor Support for Training, Mastery Experience, and Access to Training. [PDF]
Front Psychol, 2021 Ooi PB, Wan Jaafar WM, Crosling G.
europepmc +1 more source