Results 151 to 160 of about 85,911 (303)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Supervisor Support and Job Performance among Nurses in Public Hospitals [PDF]

, 2019
The aim of this study is to investigate the relationship between supervisor support and job performance among nurses. On the basis of self-reported data from 718 Staff Nurses in Malaysia’s public hospitals, this study found that there is no significant ...
Novia Zahrah, Azelin Aziz, Siti Abdul Hamid   +2 more
core  

An Empirical Study Analyzing the Moderating Effect of Supervisor Support and Mediating Effect of Presenteeism among Eustress, Distress, and Innovative Behavior. [PDF]

Behav Sci (Basel), 2023
Anjum A, Zhao Y, Faraz N.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Perceived Supervisor Support for Health Affects Presenteeism: A Cross-Sectional Study. [PDF]

Int J Environ Res Public Health, 2022
Mori T, Nagata T, Nagata M, Odagami K, Mori K.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Graduate Students' Perceived Supervisor Support and Innovative Behavior in Research: The Mediation Effect of Creative Self-Efficacy. [PDF]

Front Psychol, 2022
Han J, Liu N, Wang F.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The relationship between discriminatory work environment and psychological distress in Italian organizations: Are lack of supervisor support and economic stress mediating factors? [PDF]

Journal of Health and Social Sciences
Introduction:The construct of a discriminatory work environment is becoming increasingly significant in organizations due to its potential impact on corporate, health, and economic stress.
Giorgia BONDANINI, Gabriele GIORGI, Francesco CHIRICO, Amelia RIZZO, Hicham KHABBACHE, Francesca ROMANA TESTA, Giulia FOTI, Federico ALESSIO, Valerio VINCIARELLI, Georgia Libera FINSTAD   +9 more
doaj  

How Does Employees' Narcissism Influence Organizational Commitment? The Role of Perceived Supervisor Support and Abusive Supervision. [PDF]

Front Psychol, 2022
Yu B, Meng Y, Li C, Liu D.
europepmc   +1 more source