Results 61 to 70 of about 67,545 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Supervisor Feedback and Innovative Work Behavior: The Mediating Roles of Trust in Supervisor and Affective Commitment

Frontiers in Psychology, 2020
This study aimed to explore how the mechanisms of supervisor feedback affect innovative work behavior (IWB) among local government employees and to examine the mediating roles of trust in supervisor and affective commitment, using organizational support ...
HyeonUk Bak
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Impact of Perceived Supervisor Support on OCB: The Moderating Effect of Introversion

The Lahore Journal of Business, 2016
This study examines the extent to which introversion moderates the relationship between perceived supervisor support and organizational citizenship behavior (OCB).
Naheed Sultana, Osaid Rabie, Mariam Farooq, Ayesha Amjad   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The prediction power of job involvement by perceived support of supervisor and coworkers

بهداشت و ایمنی کار, 2013
Introduction: Researches show that workplace quality play important role in developing job involvement. The purpose of this study was to determine the predicted power of job involvement by perceived supervisor support and perceived coworker support ...
F. kiani, M. R. Khodabakhsh
doaj  

The importance of supervisor support for the work outcomes and psychological well-being of Malaysian low-income working mothers

Psikohumaniora: Jurnal Penelitian Psikologi
Low-income working mothers are susceptible to well-being issues. However, research on the interplay between supervisor support and the work outcomes and psychological well-being of Malaysian low-income working mothers is scarce.
Syara Shazanna Zulkifli, Hazalizah Hamzah   +1 more
doaj   +1 more source

Scalable Semi-Supervised Support Vector Machine Based on Adaptive Sampling [PDF]

, 2023
Xinyue Evelyn Zhao, Xiaoyang Sun, Jing Zhang, Yunsheng Song   +3 more
openalex   +1 more source