Results 111 to 120 of about 387,639 (348)

Hysteresis-based supervisory control with application to non-pharmaceutical containment of COVID-19. [PDF]

open access: yesAnnu Rev Control, 2021
Bin M   +6 more
europepmc   +1 more source

Supervisor Localization of Discrete-Event Systems based on State Tree Structures

open access: yes, 2013
Recently we developed supervisor localization, a top-down approach to distributed control of discrete-event systems in the Ramadge-Wonham supervisory control framework.
Cai, Kai, Wonham, W. M.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Experimental evaluation of the concept of supevisory manipulation [PDF]

open access: yes
A computer-controlled teleoperator system which is based on task-referenced sensor-aided control has been developed to study supervisory manipulation. This system, called SUPERMAN, is capable of performing complicated tasks in real-time by utilizing the ...
Brooks, T. L., Sheridan, T. B.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Supervisory control of quantitative Petri nets for fixed‐initial‐credit energy problems using a game structure

open access: yesIET Control Theory & Applications
This work investigates quantitative supervisory control of discrete event systems modeled with Petri nets under the fixed‐initial‐credit energy objective.
Yuling Zhang   +3 more
doaj   +1 more source

Modeling and supervisory control design for a combined cycle power plant [PDF]

open access: yes, 2012
The traditional control strategy based on PID controllers may be unsatisfactory when dealing with processes with large time delay and constraints. This paper presents a supervisory model based constrained predictive controller (MPC) for a combined cycle ...
Abokhatwa, Salah, Katebi, Reza
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

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