Results 41 to 50 of about 664,970 (318)

Determination of Total Antioxidant Capacity in Saliva of Smokers and Non-smokers with Chronic Periodontitis

Bihdād, 2020
Background: Periodontal diseases in smokers are 2.6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is ...
Ahmadreza Mirzaei, Mahboobeh Mehrabani, Zohreh Khodaii, Hamid Mirshamsi, Nasrin Rafieian   +4 more
doaj  

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

Food & Nutrition Research, 2021
Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications.
Kristin S. Magnusdottir, Ellen A. Tryggvadottir, Ola K. Magnusdottir, Laufey Hrolfsdottir, Thorhallur I. Halldorsson, Bryndis E. Birgisdottir, Ingibjorg T. Hreidarsdottir, Hildur Hardardottir, Ingibjorg Gunnarsdottir   +8 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered

Frontiers in Neuroscience
IntroductionA water extract of Centella asiatica (L.) Urban [Apiaceae] (CAW) has demonstrated cognitive-enhancing effects in mouse models of Alzheimer’s disease and aging, the magnitude of which is influenced by whether CAW is delivered in the drinking ...
Alex B. Speers, Alex B. Speers, Kirsten M. Wright, Kirsten M. Wright, Mikah S. Brandes, Mikah S. Brandes, Nareg Kedjejian, Nareg Kedjejian, Donald G. Matthews, Maya Caruso, Christopher J. Harris, Seiji Koike, Seiji Koike, Thuan Nguyen, Thuan Nguyen, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Amala Soumyanath, Amala Soumyanath, Nora E. Gray, Nora E. Gray   +21 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Calcium Supplementation

Journal of the American Academy of Nurse Practitioners, 1997
Calcium is necessary for the prevention and treatment of diseases such as osteoporosis, hypertension, and, possibly, colon cancer. Supplementation is useful when dietary calcium intake is low, as is the current situation in North America. There are many factors to consider before recommending any one form of supplement.
S J, Whiting, R, Wood, K, Kim
openaire   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Key targets and pathways in skin photoaging: a comprehensive review

Journal of Dermatologic Science and Cosmetic Technology
In recent years, our understanding of photoaging and photoprotection has significantly advanced, with photoaging now widely recognized as a key factor affecting both the health and aesthetic quality of the skin.
Wenyi Zhu, Hankun Ren, Yueheng Liu, Zeqiao Li, Xiang Luo, Hong Meng, Yinmao Dong   +6 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source