Results 81 to 90 of about 4,363,377 (368)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Research on Classification and Identification of Crack Faults in Steam Turbine Blades Based on Supervised Contrastive Learning

Entropy
Steam turbine blades may crack, break, or suffer other failures due to high temperatures, high pressures, and high-speed rotation, which seriously threatens the safety and reliability of the equipment.
Qinglei Zhang, Laifeng Tang, Jiyun Qin, Jianguo Duan, Ying Zhou   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Forecast accuracy in demand planning: A fast-moving consumer goods case study

Journal of Transport and Supply Chain Management, 2019
Background: An established South African fast-moving consumer goods (FMCG) manufacturer, Company A, sought to address an underperforming supply chain through an attempt to improve demand planning accuracy.
Lisa M. Basson, Peter J. Kilbourn, Jackie Walters   +2 more
doaj   +1 more source

Supply chain design [PDF]

Journal of Process Management. New Technologies, 2020
In this study, the analysis will be given on “Investigating the role of Knowledge Management in the global supply chain”. For the data, collection manufacturing firms is chosen from Pakistan. The method for data collection is secondary data collection. To achieve this, a systematic review is conducted based on qualitative content analysis.
openaire   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Cross-departmental collaboration in strategic sourcing as a catalyst for supplier development: The case of Eskom

Acta Commercii, 2017
Objective: The objective was to analyse the integration of and collaboration between strategic sourcing and supplier development at Eskom, South Africa’s primary electricity supplier, and to determine how strategic sourcing can be a catalyst for supplier
Mzoxolo E. Mbiko, Tatenda Mbara, Elana Swanepoel   +2 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Ten-tier and multi-scale supplychain network analysis of medical equipment: Random failure and intelligent attack analysis [PDF]

arXiv, 2021
Motivated by the COVID-19 pandemic, this paper explores the supply chain viability of medical equipment, an industry whose supply chain was put under a crucial test during the pandemic. This paper includes an empirical network-level analysis of supplier reachability under Random Failure Experiment (RFE) and Intelligent Attack Experiment (IAE ...
arxiv  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source