Results 91 to 100 of about 723,577 (358)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

THE PERFORMANCE OF APPLE CHIPS SUPPLY CHAIN MANAGEMENT AT SMALL INDUSTRY IN BATU CITY

open access: yesAGRISE, 2018
Batu City is one of well known cities in East Java Province which is as center of tourism destination and also as center of apple production. There is growing small scale industry related to apple processed products, such as apple chips.
Dwi Retnonigsih
doaj  

The impact of artificial intelligence on sustainable development performance of public healthcare supply chain-an empirical study based on listed Chinese pharmaceutical companies

open access: yesFrontiers in Public Health
With the continuous deepening of the digital transformation of the public healthcare supply chain, as the next step of digitalization, intelligent transformation has received much attention, especially how artificial intelligence can improve the ...
Qianlan Chen   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Linking supply chain risk management to financial performance of SMEs: can supply chain collaboration moderate?

open access: yesAfrican Business Management Journal
While supply chain risk management is widely recognised for mitigating disruptions and enhancing operational efficiency, its impact on the financial performance of manufacturing small and medium-sized enterprises remains underexplored, particularly when
Michael Patrick Chuwa   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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