Results 51 to 60 of about 11,924,151 (347)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Supported Employment: A Best Practice for People with Psychiatric Disabilities [PDF]

, 2006
Over the past several decades, research from a variety of fields has presented powerful evidence of the importance of employment to people with psychiatric disabilities.
Cook, Judith A., O\u27Day, Bonnie
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

SUPPORTED EMPLOYMENT – THE WAY TO INTEGRATION AND INDEPENDENCE FOR PEOPLE IN A HOMELESSNESS CRISIS

Humanities and Social Sciences
The supported employment model for homeless people is based on a holistic approach that combines professional, housing, health, and social support.
Agnieszka MIKLEWSKA
doaj   +1 more source

Employment outcomes for people with schizophrenia spectrum disorder: A meta-analysis of randomized controlled trials

International Journal of Occupational Medicine and Environmental Health, 2017
Access to employment plays a critical role in the recovery and functioning of people with schizophrenia. We have investigated the effectiveness of treatments to enhance employment outcomes for people with schizophrenia and evaluated the potential ...
Viviana R. Carmona, Juana Gómez-Benito, Tania B. Huedo-Medina, J. Emilio Rojo   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Supported employment – ensuring flexibility or introducing new demands? – a longitudinal case from Denmark

Nordic Social Work Research
Introducing new approaches to existing services can potentially create tensions within organizations. This article demonstrates how implementing a modified Individual Placement and Support programme in unemployment services in Denmark affects ...
Stella Mia Sieling-Monas, Anne Jørgensen, Hamiyet Kaya, Inge Storgaard Bonfils   +3 more
doaj   +1 more source

Using Instructional Design, Analyze, Design, Develop, Implement, and Evaluate, to Develop e-Learning Modules to Disseminate Supported Employment for Community Behavioral Health Treatment Programs in New York State

Frontiers in Public Health, 2018
BackgroundImplementation science lacks a systematic approach to the development of learning strategies for online training in evidence-based practices (EBPs) that takes the context of real-world practice into account.
Sapana R. Patel, Sapana R. Patel, Paul J. Margolies, Paul J. Margolies, Nancy H. Covell, Nancy H. Covell, Cristine Lipscomb, Lisa B. Dixon, Lisa B. Dixon   +8 more
doaj   +1 more source

High-Performing States in Integrated Employment [PDF]

, 2003
[Excerpt] Between 1988 and 1996, the number of individuals supported by state mental retardation/developmental disabilities (MR/DD) agencies who participated in some type of community employment increased by 200%.
Institute for Community Inclusion
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source