Results 61 to 70 of about 314,869 (336)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Supported employment in Norway [PDF]

open access: yes, 2004
This report presents research on the Norwegian labour market measure Arbeid med bistand (AB). AB is a national mainstream supported employment programme, which provides support aimed at the inclusion of vocationally disabled job seekers in the ordinary ...
Spjelkavik, Øystein   +2 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Identifying the Pattern of Job Coaching Skills on Supported Employment in Adults with Intellectual Disability: A Thematic Analysis Study [PDF]

open access: yesپژوهش‌های علوم شناختی و رفتاری
Supported employment is a successful approach in the vocational rehabilitation of adults with intellectual disabilities, and is highly dependent on job coaching.
Hamidreza Sharifi Jondani   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

[How can the mentally ill achieve sustained employment? Supported employment versus pre-vocational training] [PDF]

open access: yes, 2012
People with severe mental disorders are often without work, although work may have a positive effect on their health. The paper presents some results in this field from the German S3 guidelines on psychosocial therapies.
Brieger, P, Hoffmann, H
core   +1 more source

Predicting satisfaction with vocational status among people with serious mental illness in vocational services: the role of perceived skills and support

open access: yesFrontiers in Psychiatry
BackgroundThis study aimed to explore the role of perceived skills and support in satisfaction with vocational status to better address the vocational needs and recovery goals of individuals with serious mental illness (SMI).
Gili Hoter Ishay   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Employment opportunities for adults with the label of 'learning difficulties' in England [PDF]

open access: yes, 2006
This study considered employment opportunities and realities of work for adults with learning difficulties in England (post the 2001, White Paper Valuing People) with the view to developing opportunities for people in Iran.
Norouzi, Ghasem
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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