Results 81 to 90 of about 314,869 (336)
Real jobs, learning difficulties and supported employment [PDF]
, 2003 Supported employment is now regarded as a major vehicle for enabling people with 'learning difficulties' to enter employment. The purpose of this paper is to use the evidence provided by three case studies of people with 'learning difficulties' who have ...
Wilson, Alastair
core +1 more source
The Potential of Technology for Enhancing Individual Placement and Support Supported Employment
Psychiatric rehabilitation journal, 2014 Topic The potential of technology to enhance delivery and outcomes of Individual Placement and Support (IPS) supported employment. Purpose IPS supported employment has demonstrated robust success for improving rates of competitive employment among ...
Sarah E Lord +8 more
semanticscholar +1 more source
SocietiesSupported employment programs are widely implemented to improve vocational outcomes for people with severe mental illness, yet evaluations of these programs employ highly heterogeneous approaches to costing and outcome measurement.
Kuo-Yi Jade Chang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Supported employment : persons with learning difficulties in Malaysia [PDF]
Many studies in the minority world have emphasized the potentially positive influences of supported as opposed to sheltered employment on the inclusion of persons with disabilities, including learning difficulties, into the mainstream economy and ...
Wan Abdullah, Wan Arnidawati
core
Does Individual Placement and Support satisfy the users` needs?
Frontiers in Public Health, 2015 This study aims to investigate clients’ satisfaction with Individual Placement and Support (IPS) at the University Hospital for Psychiatry Zurich (PUK).
Sandra eViering +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source