Results 81 to 90 of about 12,024,358 (339)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The social & economic implications of alternative land uses involving pastoral farming and forestry in Northland : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Natural Resource and Environmental Economics at Massey University [PDF]

, 1987
This thesis is a scenario study which examines the social and economic impacts of different types of forestry being established in an area of pastoral farmland in Northland, New Zealand.
Smith, David Hardie
core   +1 more source

High-Performing States in Integrated Employment [PDF]

, 2003
[Excerpt] Between 1988 and 1996, the number of individuals supported by state mental retardation/developmental disabilities (MR/DD) agencies who participated in some type of community employment increased by 200%.
Institute for Community Inclusion
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Analysis of factors influencing satisfaction with vocational rehabilitation services for young persons with disabilities in Sweden

Frontiers in Rehabilitation Sciences
PurposeThe purpose of this study is to identify what factors influence user satisfaction with vocational rehabilitation services among service users in a Swedish context.MethodsIn a randomized control trial, ordinal logistic regression was applied to a ...
Johanna Gustafsson, Johanna Gustafsson, Johanna Gustafsson, Ingrid Witte, Ingrid Witte, Ingrid Witte   +5 more
doaj   +1 more source

Enhancing Autonomy through the Occupational Engagement of Adults with Intellectual Disabilities: Supported Employment Model Applied by the Polish Association for Persons with Intellectual Disabilities (Branch in Zgierz)

Przeglad Socjologii Jakosciowej, 2019
Reflections presented in this paper reverberate with the current social discourse based on respect for human rights, with heavy emphasis put on the active policy of employment of persons with disabilities.
Grażyna Mikołajczyk-Lerman, Małgorzata Potoczna   +1 more
doaj   +1 more source

Would you train me with my mental illness? Evidence from a discrete choice experiment [PDF]

The low employment among people with disabilities in general, and mental disorders in particular, generates high costs to the society. This raises the need to develop effective vocational rehabilitation methods.
Deuchert, Eva, Kauer, Lukas, Meisen Zannol, Flurina   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Review of Recent Evaluation Efforts Associated with Programs and Policies Designed to Promote the Employment of Adults with Disabilities [PDF]

, 2009
The purpose of this report is to provide a review of the recent evaluation activities being conducted for a number of state and federal programs, policies, and initiatives designed to promote the employment of people with disabilities.
Livermore, Gina A., Goodman, Nanette
core   +1 more source