Results 91 to 100 of about 12,024,358 (339)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The employer's perspective: employment of people with disabilities in wage subsidized employments

Scandinavian Journal of Disability Research, 2013
The aim of this article is to examine employers' perspectives of the conditions of employment of people with disabilities within a context of wage subsidies.
Johanna Gustafsson, Julia Prieto Peralta, Berth Danermark   +2 more
doaj   +1 more source

Go for It! Supporting people with learning disabilities and / or Autistic Spectrum Disorders in Employment [PDF]

, 2005
This study, commissioned to inform The same as you? National Implementation Group, looked at what employment support there is in Scotland for people with learning disabilities and/or autistic spectrum disorders (ASD) and identified good practice.
Hunter, Susan, Infusion Co-operative, Ridley, Julie   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Distinct Value of Occupational Therapy in Supported Employment of Adults with Intellectual Disabilities

Open Journal of Occupational Therapy, 2018
Background: Supported employment provides individuals with intellectual disabilities (ID) the support needed for community work. ID work is an integral occupation of adult life, facilitates social interaction, and fosters a sense of accomplishment and ...
Katie Coakley, Kimberly Bryze
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Merging Evidence-Based Psychosocial Interventions in Schizophrenia

Behavioral Sciences, 2014
Psychosocial interventions are an essential part of the treatment for people with severe mental illness such as schizophrenia. The criteria regarding what makes an intervention “evidence-based” along with a current list of evidence-based interventions ...
Tania Lecomte, Marc Corbière, Stéphanie Simard, Claude Leclerc   +3 more
doaj   +1 more source

The motivation to migrate, acculturation, and finding employment : the case of African migrants in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of a Master of Arts in Psychology at Massey University [PDF]

, 2008
The present study tested a model whereby Psychological Acculturation mediated the relationship between the Psychological Motives to Migrate and the Employment Outcome of African migrants in New Zealand.
Udahemuka, Martine Marie-Gloria
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Work organisation in industry: Practices of use of IT in Portugal [PDF]

The innovation in the employment behaviour is particularly clear in what concerns the sector composition of the employment changes: the persistent decrease of the industrial employment (even if within a framework of some recovery of the industrial ...
Moniz, António
core   +1 more source