Results 101 to 110 of about 314,869 (336)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The Entrepreneurial Model of Supported Employment [PDF]

, 1992
Existing supported employment models have provided vocational education and job placement opportunities for special education students. These models of supported employment have limited utility in rural settings due to low population density, great ...
Joe Ferrara, Robert Markve, Randall Morris, Eric Rudrud   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The employer's perspective: employment of people with disabilities in wage subsidized employments

Scandinavian Journal of Disability Research, 2013
The aim of this article is to examine employers' perspectives of the conditions of employment of people with disabilities within a context of wage subsidies.
Johanna Gustafsson, Julia Prieto Peralta, Berth Danermark   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Social firms as a means of vocational recovery for people with mental illness : a UK survey [PDF]

, 2013
Background: Employment is associated with better quality of life and wellbeing in people with mental illness. Unemployment is associated with greater levels of psychological illness and is viewed as a core part of the social exclusion faced by people ...
Marwaha, Steven, Morant, Nicola, Marwaha, S, Parsons, Nicholas, Parsons, Nicholas R., Morant, N, Eleanor Gilbert, Swaran Singh, Nicholas Parsons, Johnson, Sonia, Milton, A, Nicola Morant, Milton, Alyssa, Gilbert, E., Singh, Swaran, Johnson, S, Gilbert, E, Singh, S, Fisher, Adrian, Di Cunliffe, Gilbert, Eleanor, Fisher, A., Steven Marwaha, Sonia Johnson, Singh, Swaran P., Fisher, A, Alyssa Milton, Marwaha, Steven; id_orcid, Parsons, N, Adrian Fisher, Cunliffe, D, Cunliffe, Di   +31 more
core   +1 more source

The Distinct Value of Occupational Therapy in Supported Employment of Adults with Intellectual Disabilities

Open Journal of Occupational Therapy, 2018
Background: Supported employment provides individuals with intellectual disabilities (ID) the support needed for community work. ID work is an integral occupation of adult life, facilitates social interaction, and fosters a sense of accomplishment and ...
Katie Coakley, Kimberly Bryze
doaj   +1 more source

Effort-based decision-making as a determinant of supported employment outcomes in psychotic disorders. [PDF]

Schizophr Res, 2023
Le TP, Green MF, Wynn JK, Iglesias JE, Franco RL, Kopelowicz A, Kern RS.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Test re-test reliability of an employment outcomes instrument (EOI) [PDF]

, 2000
Plan BPersons with disabilities are one of societies most disadvantaged groups. They experience unfair discrimination and prejudice and are subject to unemployment and poverty.
Hisman, Kristy
core