Results 121 to 130 of about 3,251,666 (288)

Critical elements in the experience of virtual reality job interview training for unemployed individuals with serious mental illness: Implications for IPS supported employment. [PDF]

Psychiatr Rehabil J, 2023
Blajeski SM, Smith MJ, Harrington MM, Johnson JM, Oulvey EA, Mueser KT, McGurk SR, Razzano LA.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

YESS: A feasibility study of a supported employment program for youths with mental health disorders. [PDF]

Front Psychiatry, 2022
Ow N, Marchand K, Glowacki K, Alqutub D, Mathias S, Barbic SP.   +5 more
europepmc   +1 more source

Fiscal systems and female employment in Europe [PDF]

, 2009
Before the economic crisis set in, there was evidence of some convergence on the Lisbon target employment rate for women (Eurostat Statistics in Focus 99/2008).
Camilleri-Cassar, Frances, Verashchagina, Alina, Bettio, Francesca, EU Expert Group on Gender and Employment (EGGE)   +3 more
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Survey of Employment Tribunal Applications, 2018

, 2021
copyright UK Data Service and data collection copyright owner.The Survey of Employment Tribunal Applications (SETA) series aims to provide information on the characteristics of the parties in, and the key features of, employment ...
Department for Business, Innovation and Skills, Employment Market Analysis and Research
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Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Call to action

, 2010
Joyce Dean, Dean/Ross Associates, and Cesilee Coulson, the Washington Initiative for Supported Employment.Title from PDF cover (viewed on April 22, 2020)."The Employment First Outreach Project."This archived document is maintained by the State Library of

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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Meaningful Work and Satisfaction with Life: A Case Study from a Supported Employment Program-Colombia. [PDF]

Behav Sci (Basel), 2022
Grueso Hinestroza MP, Antón C, López-Santamaría M.   +2 more
europepmc   +1 more source