Results 141 to 150 of about 314,869 (336)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Handbook Supported Employment [PDF]

, 2007
[Excerpt] Supported employment has brought about improvements in the quality of life of women and men with a disability by enabling them to become active participants in society.
Kamp, Michael, Lynch, Christy
core   +1 more source

Effect of Evidence-Based Supported Employment vs Transitional Work on Achieving Steady Work Among Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial

JAMA psychiatry, 2018
L. Davis, T. Kyriakides, A. Surís, Lisa Ottomanelli, Lisa Mueller, Pamela E. Parker, S. Resnick, Richard Toscano, A. Scrymgeour, R. Drake   +9 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Supported Employment: the employment consultants' perspective [PDF]

, 2011
Supported employment (SE) organisations work to support people with mental illness into employment. This study sought to examine the experiences and perspectives of staff that work for a SE service.
Kliem, Alexis
core   +2 more sources

YESS: A feasibility study of a supported employment program for youths with mental health disorders. [PDF]

Front Psychiatry, 2022
Ow N, Marchand K, Glowacki K, Alqutub D, Mathias S, Barbic SP.   +5 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Meaningful Work and Satisfaction with Life: A Case Study from a Supported Employment Program-Colombia. [PDF]

Behav Sci (Basel), 2022
Grueso Hinestroza MP, Antón C, López-Santamaría M.   +2 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Supported Employment and People with Learning Difficulties [PDF]

, 2008
The aim of this dissertation is to introduce the program supported employment. This service is supposed to help people with learning difficulties becoming usefull to the open job.
Novák, Ondřej
core