Results 131 to 140 of about 12,024,358 (339)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Impact of Subsidies on Czech Firms [PDF]

open access: yesStatistika: Statistics and Economy Journal, 2013
In the Czech Republic there has been invested a lot of money to the human capital through the European Social Fund. The Human Resources and Employment Operational Programme plays an important role by providing subsidies for the training of employees and ...
Oto Potluka   +4 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Effects of Minimum Wages on Employment: Theory and Evidence from the US [PDF]

open access: yes
Recent work on the economic effects of minimum wages has stressed that the standard economic model, where increases in minimum wages depress employment, is not supported by the empirical findings in some labour markets.
Alan Manning   +2 more
core  

Reducing gender inequalities to create a sustainable care system [PDF]

open access: yes, 2008
Women mainly provide family care, but as women’s economic opportunities increase they will not continue to bear the costs of providing care unaided. To create a sustainable care system, care and carers must be better supported and more highly valued to ...
Himmelweit, Susan, Land, Hilary
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Development of the Supported Employment, Comprehensive Cognitive Enhancement, and Social Skills program for adults on the autism spectrum: Results of initial study

open access: yesAutism, 2018
Mary J. Baker-Ericzén   +10 more
semanticscholar   +1 more source

Munkapiaci áramlások, gereblyézés és a 2008 végén kibontakozó gazdasági válság foglalkoztatási hatásai [PDF]

open access: yes, 2010
Analyses of the Hungarian employment situation are almost always concerned only with the change in the number of the employed, unemployed and inactive, not paying particular attention to the flows between these states.
Cseres-Gergely, Zsombor
core  

Home - About - Disclaimer - Privacy