Results 231 to 240 of about 2,656,520 (276)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +1 more source

Dynamical Heterogeneity in Supported Lipid Bilayers

MRS Bulletin, 2006
Planar-supported phospholipid bilayers are responsive surfaces that reconstruct when macromolecules adsorb. This review outlines the phenomenon of lipid diffusion “slaved” to or significantly controlled by that of macromolecular adsorbates. To elucidate such systems, we discuss the value of spatially resolved experiments at the few-molecule level ...
Zhang, Liangfang, Granick, Steve
openaire   +3 more sources

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Cell adhesion on supported lipid bilayers

Journal of Biomedical Materials Research Part A, 2003
AbstractThe cell and protein repellent properties of supported phospholipid bilayer (SPB) membranes were investigated. The SPBs were prepared by vesicle adsorption on SiO2 surfaces. The vesicles of phosphatidylcholine fuse and rupture, and form a supported bilayer covering the surface.
Ann-Sofie, Andersson, Karin, Glasmästar, Duncan, Sutherland, Ulf, Lidberg, Bengt, Kasemo   +4 more
openaire   +2 more sources

On the Effect of the Solid Support on the Interleaflet Distribution of Lipids in Supported Lipid Bilayers

Langmuir, 2004
The adsorption and spreading of lipid vesicles on solid supports has become a popular way to create supported lipid bilayers (SLBs), but little attention has been paid to the possible redistribution of lipid material between the two leaflets of an SLB. We use the technique of quartz crystal microbalance with dissipation monitoring (QCM-D) to follow the
Richter, R., Maury, N., Brisson, A.
openaire   +3 more sources

Incorporation of Ubiquinone in Supported Lipid Bilayers on ITO

The Journal of Physical Chemistry B, 2013
Ubiquinone (UQ) is one of the main electron and proton shuttle molecules in biological systems, and dipalmitoylphosphatidylcholine (DPPC) is one of the most used model lipids. Supported planar bilayers (SPBs) are extensively accepted as biological model membranes.
Hoyo Pérez, Javier, Guaus Guerrero, Ester, Oncins, Gerard, Torrent Burgués, Juan, Sanz Carrasco, Fausto   +4 more
openaire   +4 more sources

Effect of cholesterol on the fluidity of supported lipid bilayers

Colloids and Surfaces B: Biointerfaces, 2020
The lateral mobility serves as a key function of the cell membrane and can be regulated by the cholesterol. Here supported lipid bilayers were used to quantitatively analyse the influence of cholesterol on the fluidity of lipid bilayer in the environments with and without an electric field.
Zhang, Ying, Li, Qingchuan, Dong, Mingdong; id_orcid 0000-0002-2025-2171, Han, Xiaojun   +3 more
openaire   +3 more sources

Quantification of the Layer of Hydration of a Supported Lipid Bilayer

Langmuir, 2010
Dual polarization interferometry (DPI) and quartz-crystal microgravimetry (QCM-D) were used to investigate the adsorption of DOPC vesicles to a solid hydrophilic surface. The layer of hydration formed between a self-assembled DOPC bilayer and a silica solid support was probed in assemblies constructed using H(2)O and D(2)O buffers.
Theodore J, Zwang, Will R, Fletcher, Thomas J, Lane, Malkiat S, Johal   +3 more
openaire   +2 more sources

Titration Force Microscopy on Supported Lipid Bilayers

Analytical Chemistry, 2005
The use of chemically modified atomic force microscopy (AFM) probes allows us to measure the surface charges of supported planar lipid bilayers with high sensitivity through the force spectroscopy operation mode. By controlling the chemistry of the tip, we can perform a classical analytical chemistry titration where the titration agent is a weak acid ...
Garcia-Manyes, S, Gorostiza, P, Sanz, F
openaire   +3 more sources

Disruption of Supported Lipid Bilayers by Semihydrophobic Nanoparticles

Journal of the American Chemical Society, 2011
Understanding the interaction between functional nanoparticles and cell membranes is critical to use nanomaterials for broad biomedical applications with minimal cytotoxicity. In this work, we have investigated the effect of adsorbed semihydrophobic nanoparticles (NPs) on the dynamics and morphology of model cell membranes.
Benxin, Jing, Yingxi, Zhu
openaire   +2 more sources