Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. [PDF]
PLoS ONE, 2009 BACKGROUND:Growth and division of Saccharomyces cerevisiae is dependent on the action of SNARE proteins that are required for membrane fusion. SNAREs are regulated, through a poorly understood mechanism, to ensure membrane fusion at the correct time and ...
Daniel C Williams, Peter J Novick
doaj +1 more source
Transgenic Suppression of AGAMOUS Genes in Apple Reduces Fertility and Increases Floral Attractiveness. [PDF]
PLoS ONE, 2016 We investigated the ability of RNA interference (RNAi) directed against two co-orthologs of AGAMOUS (AG) from Malus domestica (domestic apple, MdAG) to reduce the risks of invasiveness and provide genetic containment of transgenes, while also promoting ...
Amy L Klocko +5 more
doaj +1 more source
Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]
, 2017 Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D +1 more
core +1 more source
WormBook, 2005 Genetic suppression has provided a very powerful tool for analyzing C. elegans. Suppression experiments are facilitated by the ability to handle very large numbers of individuals and to apply powerful selections. Because the animal grows as a self-fertilizing diploid, both dominant and recessive suppressors can be recovered.
openaire +2 more sources
Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy. [PDF]
PLoS ONE, 2012 BackgroundGood adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, some patients remain virologically suppressed despite suboptimal adherence.
Tracy R Glass +14 more
doaj +1 more source
Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD). [PDF]
, 2016 There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and ...
Cadenhead, Kristin S +4 more
core +1 more source
The real war on cancer: the evolutionary dynamics of cancer suppression. [PDF]
, 2012 Cancer is a disease of multicellular animals caused by unregulated cell division. The prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer results after a series of (generally somatic) mutations that knock out the ...
Nunney, Leonard
core +1 more source
Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2016 The concept of "protein-based inheritance" defines prions as epigenetic determinants that cause several heritable traits in eukaryotic microorganisms, such as Saccharomyces cerevisiae and Podospora anserina.
Anton A Nizhnikov +6 more
doaj +1 more source
Wolbachia versus dengue: Evolutionary forecasts. [PDF]
, 2013 A novel form of biological control is being applied to the dengue virus. The agent is the maternally transmitted bacterium Wolbachia, naturally absent from the main dengue vector, the mosquito Aedes aegypti.
Bull, James J, Turelli, Michael
core +1 more source
A grating lobe suppression method for displaced subarrays using genetic algorithm
IET Microwaves, Antennas & Propagation, 2022 The large‐element‐spacing array is often used to reduce the channels and costs of the phased array. However, it will form grating lobes (GLs) in the visible space, which decrease the performance. The displaced subarray technique has strong GL suppression
Lei Yang, Kan Wang, Hongbing Sun
doaj +1 more source