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Tumor suppressor genetics [PDF]

Carcinogenesis, 2005
The observation that mutations in tumor suppressor genes can have haploinsufficient, as well as gain of function and dominant negative, phenotypes has caused a reevaluation of the 'two-hit' model of tumor suppressor inactivation. Here we examine the history of haploinsufficiency and tumor suppressors in order to understand the origin of the 'two-hit ...
Shannon R, Payne, Christopher J, Kemp
openaire   +2 more sources

Tumor Suppressor Genes [PDF]

Research Journal of Medical Sciences, 2010
Tumour suppressor genes are a class of genes that have a crucial role in the genesis of neoplasia. These genes when transcribed and translated, result in the production of proteins that regulate the cell cycle, repair any DNA mutations and control apoptosis.
Gamudi, Donia, Blundell, Renald
openaire   +2 more sources

The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

Frontiers in Oncology, 2020
miR-372 has been shown a potent oncogenic miRNA in the pathogenesis of oral squamous cell carcinoma (OSCC). The zinc finger and BTB domain containing 7A protein (ZBTB7A) is a transcriptional regulator that is involved in a great diversity of ...
Li-Yin Yeh, Cheng-Chieh Yang, Cheng-Chieh Yang, Cheng-Chieh Yang, Hsiao-Li Wu, Shou-Yen Kao, Shou-Yen Kao, Chung-Ji Liu, Chung-Ji Liu, Yi-Fen Chen, Shu-Chun Lin, Shu-Chun Lin, Shu-Chun Lin, Kuo-Wei Chang, Kuo-Wei Chang, Kuo-Wei Chang   +15 more
doaj   +1 more source

Analysis of the Plasmid-Based ts-Mutant ΔfabA/pTS-fabA Reveals Its Lethality under Aerobic Growth Conditions That Is Suppressed by Mild Overexpression of desA at a Restrictive Temperature in Pseudomonas aeruginosa

Microbiology Spectrum, 2023
It is uncertain whether PA1610|fabA is essential or dispensable for growth on LB-agar plates under aerobic conditions in Pseudomonas aeruginosa PAO1.
Liyan Tian, Zhili Yang, Jianxin Wang, Jianhua Liu   +3 more
doaj   +1 more source

The Hippo pathway in disease and therapy: cancer and beyond

Clinical and Translational Medicine, 2014
The Hippo tumour suppressor pathway co‐ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal inputs on different levels to ensure the ...
Marta Gomez, Valenti Gomez, Alexander Hergovich   +2 more
doaj   +1 more source

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

mSphere, 2020
The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V.
Chelsea S. Rule, Young-Jun Park, Jaclyn R. Delarosa, Stewart Turley, Wim G. J. Hol, Sarah McColm, Colby Gura, Frank DiMaio, Konstantin V. Korotkov, Maria Sandkvist   +9 more
doaj   +1 more source

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control

Nature Communications, 2017
The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they
Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad A. D. Sharif, Celia Lujan, Ewan St. John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich   +14 more
doaj   +1 more source

Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC

Frontiers in Immunology, 2020
Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality.
Kelvin Anderson, Nathan Ryan, Greta Volpedo, Greta Volpedo, Sanjay Varikuti, Abhay R. Satoskar, Abhay R. Satoskar, Steve Oghumu   +7 more
doaj   +1 more source

Prediction Of Cancer Possibility By Pattern Recognition And Statistical Study Of Expression Of Gene Level Of Cancer Cells [PDF]

, 2011
The activity of the p53 tumor-suppressor protein has a key role in controlling both cancer and aging: under activity encourages the growth of cancer, and over activity can accelerate the aging process.
Devang Odedra, Medhavi Mallick
core   +2 more sources

P25 and P37 proteins encoded by firespike leafroll-associated virus are viral suppressors of RNA silencing

Frontiers in Microbiology, 2022
Firespike leafroll-associated virus (FLRaV) is a major pathogen associated with firespike (Odontonema tubaeforme) leafroll disease. Phylogenetic analysis showed that FLRaV possesses typical traits of subgroup II members of ampeloviruses, but encodes two ...
Yaqin Wang, Hui Liu, Zhanqi Wang, Yushuang Guo, Tao Hu, Xueping Zhou, Xueping Zhou   +6 more
doaj   +1 more source