Results 101 to 110 of about 36,798 (270)

Synchronization-induced rhythmicity of circadian oscillators in the suprachiasmatic nucleus.

PLoS Computational Biology, 2007
The suprachiasmatic nuclei (SCN) host a robust, self-sustained circadian pacemaker that coordinates physiological rhythms with the daily changes in the environment.
Samuel Bernard, Didier Gonze, Branka Cajavec, Hanspeter Herzel, Achim Kramer   +4 more
doaj   +1 more source

Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Molecular Metabolism, 2019
Objective: A network of endogenous circadian clocks adapts physiology and behavior to recurring changes in environmental demands across the 24-hour day cycle. Circadian disruption promotes weight gain and type 2 diabetes development.
Isa Kolbe, Brinja Leinweber, Matthias Brandenburger, Henrik Oster   +3 more
doaj   +1 more source

Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function [PDF]

, 2007
Pacemakers are functional units capable of generating oscillations that synchronize downstream rhythms. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is a circadian pacemaker composed of individual neurons that intrinsically express a
Kuhlman, S. J.
core   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, Volume 4, Issue 1, Page 36-54, February 2026.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

PPARg mRNA in the adult mouse hypothalamus: distribution and regulation in response to dietary challenges

Frontiers in Neuroanatomy, 2015
Peroxisome proliferator-activated receptor gamma (PPARg) is a ligand-activated transcription factor that was originally identified as a regulator of peroxisome proliferation and adipocyte differentiation.
Yang eLiu, Ying eHuang, Syann eLee, Angie L Bookout, Carlos M Castorena, Wua eHu, Laurent eGautron   +6 more
doaj   +1 more source

Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus [PDF]

, 2006
Light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells. Previous work raised the possibility that brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related receptor kinase ...
Allen, Allen, Antle, Blum, Chao, Colwell, Ding, Gottesman, Hannibal, Hannibal, Hayashi, Herzog, Jelsma, Jobst, Lavezzari, Lee, Lessmann, Levine, Liang, Liang, Lin, Lundkvist, Michel, Michel, Moore, Morin, Nagappan, Nong, Obrietan, Rajagopal, Roenneberg, Schinder, Suzuki, Tischkau, Van Gelder, Vecino, Wu, Xu   +37 more
core   +1 more source

Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals.
Rahim Badrfam, Atefeh Zandifar
wiley   +1 more source

The circadian system alters thermoregulation depending on the time of day and feeding condition [PDF]

, 2009
The circadian rhythm of body temperature (Tb) is a well-known phenomenon. However, it is unknown how the circadian system affects thermoregulation. Food deprivation in mice induces a greater reduction of Tb particularly in the light phase.
Kei Nagashima, Ken Tokizawa, Yuki Uchida
core   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, Volume 158, Issue 3, Page 775-789, 1 February 2026.
What's new? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

eLife, 2017
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment.
Kylie S Chew, Jordan M Renna, David S McNeill, Diego C Fernandez, William T Keenan, Michael B Thomsen, Jennifer L Ecker, Gideon S Loevinsohn, Cassandra VanDunk, Daniel C Vicarel, Adele Tufford, Shijun Weng, Paul A Gray, Michel Cayouette, Erik D Herzog, Haiqing Zhao, David M Berson, Samer Hattar   +17 more
doaj   +1 more source