Results 81 to 90 of about 34,337 (216)

Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]

, 2017
In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita, Brooks, George A, Efe, Gizem, Garan, Steven A, Gouw, Arvin M, Mehdizadeh, Morvarid, Preecha, Andrew   +6 more
core   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

Mouse circadian plasma leptin and active ghrelin rhythms under ad libitum and scheduled feeding [PDF]

, 2007
Thesis (M.S.) University of Alaska Fairbanks, 2007Light is the strongest timing cue for the circadian system, but non-photic cues can also entrain the master circadian clock, i.e., suprachiasmatic nuclei (SCN).
Wan, Haiting
core  

SIRT1: Protean roles at the nexus of health, disease, and therapeutics

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
SIRT1 serves as a central regulator linking metabolism, stress responses, and disease. It influences diverse processes, including transcriptional and posttranscriptional gene expression and protein activity, inflammation, mitochondrial function, and cell survival, through the deacetylation of multiple protein targets. While SIRT1 often plays protective
Brahim Chaqour
wiley   +1 more source

Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time

Frontiers in Endocrinology, 2019
Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles.
Ronald McCarthy, Emily S. Jungheim, Justin C. Fay, Keenan Bates, Erik D. Herzog, Sarah K. England   +5 more
doaj   +1 more source

Physiological Implications of Prolonged Selenium Administrations in Normal and Desynchronized Adult Female Rats [PDF]

Journal of Krishna Institute of Medical Sciences University, 2021
Background: Owing to the non-biodegradability of selenium, its prolonged consumption may lead to adverse health outcomes. Aim and Objectives: The study investigated the physiological effects of prolonged selenium administrations in normal and ...
M.J. Adeniyi, F.O. Agoreyo, S.F. Ige, O.A. Fabunmi, O.P. Ozolua, S.A. Biliaminu   +5 more
doaj  

Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]

, 2012
The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland, Helfer, Gisela, Jones, Catherine   +2 more
core   +1 more source

Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Using physiological and behavioral assays, we quantified the effectiveness and appropriateness of six commonly used fish anesthetics on zebrafish embryos. Different anesthetics performed better under different contexts. Figure prepared using BioRender.com.
Sylvia Dimitriadou, Mhairi Miller, Ali Pilehvar, Lynne U. Sneddon, Jessica L. Bamsey, Damilola Hogan‐Bassey, Maciej Trznadel, Jonathan S. Ball, Aya Takesono, Courtney Hillman, Hannah Rickard, Grace Popplewell, Jenna Corcoran, Tetsuhiro Kudoh, Charles R. Tyler, Matthew J. Winter   +15 more
wiley   +1 more source

The choroid plexus is an important circadian clock component

Nature Communications, 2018
The suprachiasmatic nucleus (SCN) has been thought of as the master circadian clock, but peripheral circadian clocks do exist. Here, the authors show that the choroid plexus displays oscillations more robust than the SCN and that can be described as a ...
Jihwan Myung, Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel, Grigory Bordyugov, Toru Takumi   +10 more
doaj   +1 more source