Results 81 to 90 of about 17,879 (182)

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

PPARg mRNA in the adult mouse hypothalamus: distribution and regulation in response to dietary challenges

Frontiers in Neuroanatomy, 2015
Peroxisome proliferator-activated receptor gamma (PPARg) is a ligand-activated transcription factor that was originally identified as a regulator of peroxisome proliferation and adipocyte differentiation.
Yang eLiu, Ying eHuang, Syann eLee, Angie L Bookout, Carlos M Castorena, Wua eHu, Laurent eGautron   +6 more
doaj   +1 more source

Expression Landscape and Circadian Regulation of lncRNAs in the Kidney

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Recent multi‐omics work shows that the diurnal rhythmicity of kidney function is associated with circadian oscillations in renal mRNA, protein and metabolite abundances. Yet circadian regulation of renal lncRNAs, which are emerging as important modulators of diverse (patho)physiological processes, remains largely unexplored. Here, we provide a
Leonore Wigger, Fanny Durussel, Muriel Auberson, Dmitri Firsov, Yohan Bignon   +4 more
wiley   +1 more source

Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Introduction Circadian dysfunction is involved in the pathophysiology of bipolar disorders (BD), and circadian‐based interventions are gaining recognition in their management. Moreover, basic and epidemiologic research has generated findings inspiring circadian‐informed self‐ and clinician‐management strategies.
Jacob J. Crouse, Victoria Loblay, Anthony Jorm, Timothy R. Wong, Zsofi de Haan, Carla Gorban, Mirim Shin, Emiliana Tonini, Chris Aiken, Lauren B. Alloy, Kürşat Altinbaş, Serge Beaulieu, Joanne S. Carpenter, Bruno Etain, Yuichi Esaki, Jess G. Fiedorowicz, Corrado Garbazza, Pierre A. Geoffroy, Bartholomeus C. M. Haarman, Tone E. G. Henriksen, Maria Paz Hidalgo, Maree L. Inder, Raymond W. Lam, Helle Ø. Madsen, Colleen A. McClung, Gunnar Morken, Laura Palagini, James Phelps, Richard J. Porter, Aswin Ratheesh, Rixt F. Riemersma‐Van der Lek, Janusz K. Rybakowski, Erika F. H. Saunders, Peter F. J. Schulte, Daniel J. Smith, Holly A. Swartz, Bryan K. Tolliver, Anna Wirz‐Justice, Ian B. Hickie, John F. Gottlieb, on behalf of the Chronobiology & Chronotherapy Task Force of the International Society for Bipolar Disorders   +40 more
wiley   +1 more source

Synchronization-induced rhythmicity of circadian oscillators in the suprachiasmatic nucleus.

PLoS Computational Biology, 2007
The suprachiasmatic nuclei (SCN) host a robust, self-sustained circadian pacemaker that coordinates physiological rhythms with the daily changes in the environment.
Samuel Bernard, Didier Gonze, Branka Cajavec, Hanspeter Herzel, Achim Kramer   +4 more
doaj   +1 more source

Suprachiasmatic nucleus [PDF]

Current Biology, 2002
openaire   +2 more sources

Alpha-synuclein expression in oxytocin neurons of young and old bovine brains

The Journal of Reproduction and Development
Understanding of central nervous system mechanisms underlying age-related infertility remains limited. Fibril α-synuclein, distinct from its monomeric form, is implicated in age-related diseases. Notably, fibril α-synuclein spreads among neurons,
Yvan Bienvenu NIYONZIMA, Yuuki ASATO, Hiroya KADOKAWA   +2 more
doaj   +1 more source

Suprachiasmatic Nucleus [PDF]

, 2020
openaire   +2 more sources

Investigating the Relationship Between Circadian Rhythm and Learning-Memory

Türk Uyku Tıbbı Dergisi
The circadian rhythm creates many metabolic changes in our body by influencing the activities of suprachiasmatic nucleus and other centers in the cerebrum according to the light-dark conditions within a 24-hour period.
Tayfun Başer, Mustafa Saygın
doaj   +1 more source

Breaching the Blood-Brain Interface: Vasoactive Neurons Contact Capillary Vessels of the Brain Clock in the Suprachiasmatic Nucleus. [PDF]

eNeuro
Yao Y, Cannava I, Tazebay R, Samuels S, Silverstein E, Silver R.   +5 more
europepmc   +1 more source