Results 61 to 70 of about 335,217 (225)
Network-level time computations in the suprachiasmatic nucleus. [PDF]
Cell ResDeciphering neuronal circuit dynamics is critical for understanding how the brain encodes information. In a recent study in Cell Research, Wang et al.
Ness N, Brancaccio M.
europepmc +2 more sources
Sensory Neuroscience, EarlyView.Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa +5 more
wiley +1 more source
Cholecystokinin receptor type A are involved in the circadian rhythm of the mouse retina
HeliyonThe retina is the only organ projecting external light to the suprachiasmatic nucleus. Cholecystokinin receptor type A (Cckar/Cckar) is one of the essential factors for light reception in retinal cells. As there was a lack of literature on the matter, we
Yusuke Yamakawa +10 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep
Sleep Science, 2016 Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations.
Zi-Jian Cai
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British Journal of Pharmacology, EarlyView.The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral +3 more
wiley +1 more source
Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms
eLife, 2016 Many animals display morning and evening bimodal activities in the day/night cycle. However, little is known regarding the potential components involved in the regulation of bimodal behavioral rhythms in mammals.
Zhipeng Qu +14 more
doaj +1 more source
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
Imaging Individual Differences in the Response of the Human Suprachiasmatic Area to Light
Frontiers in Neurology, 2018 Circadian disruption is associated with poor health outcomes, including sleep and mood disorders. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus acts as the master biological clock in mammals, regulating circadian rhythms throughout the ...
Elise M. McGlashan +6 more
doaj +1 more source
Nature Communications, 2020 Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al.
Andrew P. Patton +7 more
doaj +1 more source