Results 71 to 80 of about 33,968 (213)

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

Cell Proliferation, Volume 59, Issue 5, May 2026.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song   +8 more
wiley   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M, Caldwell JD, Caldwell JD, Caldwell JD, Caldwell JD, Christian Melle, Englebienne P, Fassler R, Feldman M, Ferdinand von Eggeling, Forunati N, Gao G, Gustav F. Jirikowski, Hammond GL, Hans-Gert Bernstein, Herbert Z, Hoskins EK, Hryb DJ, Jack D. Caldwell, Jirikowski GF, John Lewis, Joseph DR, Khan MS, Krupenko SA, Lewis JG, Melle C, Paoletti AM, Pardridge WM, Remington SG, Reventos J, Rosner W, Selva DM, Susanne Göthe, Vigh Teichmann I, Wang YM, Zsófia Herbert   +35 more
core   +1 more source

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4243-4252, May 2026.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi, Talha Rafiq, Marie Pigeyre, Renee de Mutsert, Femke Rutters, David J.T. Campbell, Jean‐Pierre Despres, Andre C. Carpentier, Joris Hoeks, Patrick Schrauwen, Parminder Raina   +10 more
wiley   +1 more source

Physiological Implications of Prolonged Selenium Administrations in Normal and Desynchronized Adult Female Rats [PDF]

Journal of Krishna Institute of Medical Sciences University, 2021
Background: Owing to the non-biodegradability of selenium, its prolonged consumption may lead to adverse health outcomes. Aim and Objectives: The study investigated the physiological effects of prolonged selenium administrations in normal and ...
M.J. Adeniyi, F.O. Agoreyo, S.F. Ige, O.A. Fabunmi, O.P. Ozolua, S.A. Biliaminu   +5 more
doaj  

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

The choroid plexus is an important circadian clock component

Nature Communications, 2018
The suprachiasmatic nucleus (SCN) has been thought of as the master circadian clock, but peripheral circadian clocks do exist. Here, the authors show that the choroid plexus displays oscillations more robust than the SCN and that can be described as a ...
Jihwan Myung, Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel, Grigory Bordyugov, Toru Takumi   +10 more
doaj   +1 more source

Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time

Frontiers in Endocrinology, 2019
Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles.
Ronald McCarthy, Emily S. Jungheim, Justin C. Fay, Keenan Bates, Erik D. Herzog, Sarah K. England   +5 more
doaj   +1 more source

Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Circadian rest/activity rhythms (RARs) change across adulthood, and alterations in RARs have been associated with cognitive decline, Alzheimer's disease (AD), and dementia. Little is known, however, about associations of RARs with subsequent changes in brain structure.
Marc A. Kaizi‐Lutu, Daniel D. Callow, Jill A. Rabinowitz, Brendan P. Lucey, Yang An, Mark N. Wu, Vadim Zipunnikov, Arnold Bakker, Christos Davatzikos, Eleanor M. Simonsick, Keenan A. Walker, Luigi Ferrucci, Susan M. Resnick, Adam P. Spira   +13 more
wiley   +1 more source

Forebrain Origins of Glutamatergic Innervation to the Rat Paraventricular Nucleus of the Hypothalamus: Differential Inputs to the Anterior Versus Posterior Subregions [PDF]

, 2011
The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to ...
Cullinan, William E, Herman, James P., Jones, Kenneth R., Ulrich-Lai, Yvonne M., Ziegler, Dana R.   +4 more
core   +3 more sources

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, MaKayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A Abou El‐Ezz, Mohammed Abou El‐Ezz, Katherina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter   +18 more
wiley   +1 more source