Results 71 to 80 of about 335,217 (225)

Blue Light Exposure During Sleep in Type 1 Diabetes: Impacts on Glycemic Control and Psychosocial Health

Journal of Sleep Research, EarlyView.
ABSTRACT Light exposure at night is linked to increased risk for obesity and insulin resistance in the general population. While sleep health is recognized as a key component of diabetes management, there has been less emphasis on nighttime light exposure. This study aimed to investigate the effects of blue and white light exposure immediately prior to
Seok Jin Hong, Sarida Pratuangtham, Pamela Martyn‐Nemeth, Alana D. Steffen, Chang Gi Park, Sirimon Reutrakul   +5 more
wiley   +1 more source

Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice [PDF]

, 2001
To investigate the role of retinal-based pigments (opsins) in circadian photoreception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free diet and tested for photic induction of gene expression in the ...
Lai, K., Thompson, C. L., Quadro, L., Van Gelder, R. N., Colantuoni, V., Gottesman, M. E., Sancar, A., Blaner, W. S.   +7 more
core   +1 more source

Retino-hypothalamic regulation of light-induced murine sleep

Frontiers in Systems Neuroscience, 2014
The temporal organization of sleep is regulated by an interaction between the circadian clock and homeostatic processes. Light indirectly modulates sleep through its ability to phase shift and entrain the circadian clock.
Fanuel eMuindi, Fanuel eMuindi, Jamie M. Zeitzer, Jamie M. Zeitzer, H Craig eHeller   +4 more
doaj   +1 more source

A Double‐Blind Randomised Controlled Crossover Trial of the Effect of Blue‐Enriched Ambient Light on Sleep in Older Adults With Sleep Disturbance: The CleverLights Study

Journal of Sleep Research, EarlyView.
ABSTRACT Light interventions have been investigated for treating sleep disturbances in older adults; however, findings are mixed. This proof‐of‐concept trial investigated the effect of blue‐enriched ambient light on electroencephalographic (EEG) sleep in older adults with self‐reported poor sleep.
Teha B. Pun, Craig L. Phillips, Nathaniel S. Marshall, Matthew Rahimi, Rick Wassing, Maria Comas, Angela L. D'Rozario, Camilla M. Hoyos, Delwyn J. Bartlett, Wenye Hu, Sharon L. Naismith, Sean Cain, Svetlana Postnova, Ronald R. Grunstein, Christopher J. Gordon   +14 more
wiley   +1 more source

The Human Suprachiasmatic Nucleus

, 2011
In mammals, the controlling clock component that generates a 24-hour rhythm is the suprachiasmatic nucleus (SCN), located in a part of the brain called the hypothalamus.
Howard Hughes Medical Institute (HHMI)
core   +1 more source

The effects of spectrum, irradiance, and duration of exposure on light‐induced melatonin suppression in healthy adults

Photochemistry and Photobiology, EarlyView.
The left panel reports the measured time course data of melatonin concentration in the blood plasma of 17 BL‐Rs and 15 BL‐NRs at baseline, during a two‐hour stay in the dark, during a one‐hour light exposure to blue light, and again in the dark. The right panel shows the magnitude of melatonin concentration after 60 min of exposure to warm white, cool ...
Helmut Piazena, Leonora Franke, Ralf Uebelhack, Thomas Penzel, Ingo Fietze   +4 more
wiley   +1 more source

Expression profiles and functional annotation analysis of mRNAs in suprachiasmatic nucleus of Clock mutant mice

, 2018
The core circadian clock gene, Clock, is a positive component of the transcription/translation feedback loop in the master pacemaker suprachiasmatic nucleus (SCN) in mammals. The robust daytime peak of some clock genes in the wild-type SCN is absent in
Mei Zhao, Guohua Ji, Li, Yinghui, Wang, Yanli, Chen, Hailong, L. Qu, Zhao, Mei, Wang, Tingmei, Hailong Chen, Yanli Wang, Ji, Guohua, Y. Li, Lina Qu, Zhang, Yongliang, Hongqing Cao, Cao, Hongqing, Liang, Fengji, Lv, Ke, Qu, Lina, Tingmei Wang, Yongliang Zhang, Ke Lv, Fengji Liang, Yinghui Li   +23 more
core   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

A Rapid and Sensitive LC–MS/MS Method for Quantification of NDSRI in Melatonin Drug Product via Controlled In Situ Formation

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Nitrosamine drug substance–related impurities (NDSRIs) pose a significant safety risk due to their mutagenic and carcinogenic potential, prompting strict regulatory oversight under ICH M7. The propensity for in situ formation of NDSRIs during analytical procedures, particularly in active pharmaceutical ingredients containing reactive amines ...
Jaya Yalamanchili, Ganja Himavathi, Salakolusu Suresh   +2 more
wiley   +1 more source

Thinking Dynamically About Biological Mechanisms: Networks of Coupled Oscillators [PDF]

, 2012
Explaining the complex dynamics exhibited in many biological mechanisms requires extending the recent philosophical treatment of mechanisms that emphasizes sequences of operations.
Bechtel, William, Abrahamsen, Adele
core