Results 61 to 70 of about 78 (77)
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Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Science, 2003Individual cellular clocks in the suprachiasmatic nucleus (SCN), the circadian center, are integrated into a stable and robust pacemaker with a period length of about 24 hours. We used real-time analysis of gene expression to show synchronized rhythms of clock gene transcription across hundreds of neurons within the mammalian SCN in ...
Takuya Matsuo +8 more
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Modeling the Electrophysiology of Suprachiasmatic Nucleus Neurons
Journal of Biological Rhythms, 2007Neurons in the SCN act as the central circadian (~24-h) pacemaker in mammals. Using measurements of the ionic currents in SCN neurons, the authors fit a Hodgkin-Huxley-type model that accurately reproduces slow (~2-8 Hz) neural firing as well as the contributions of ionic currents during an action potential.
Daniel B. Forger, Choon Kiat Sim
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Immunohistochemical characterization of the sheep suprachiasmatic nucleus.
Journal of chemical neuroanatomy, 1989Using 19 antisera raised against neuropeptides, amines or enzymes of amine biosynthesis, an immunohistochemical characterization of the sheep suprachiasmatic nucleus was performed. The most distinguishing characteristic of the sheep suprachiasmatic nucleus was the low density of serotonin- and neuropeptide Y-immunoreactive fibres; their concentration ...
Tillet, Yves, Caldani, M., Tramu, G.
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The efferent connections of the suprachiasmatic nucleus of the hypothalamus
Journal of Comparative Neurology, 1975AbstractThe efferent connections of the suprachiasmatic nucleus of the hypothalamus have been studied in the rat by the injection of 3Hâproline into the nucleus and the surrounding regions of the rostral hypothalamus, and by the injection of the enzyme marker, horseradish peroxidase, into the region of the ventromedial hypothalamic nucleus.
W. M. Cowan, Larry W. Swanson
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Primary cell culture of suprachiasmatic nucleus
Brain Research Bulletin, 2003In mammals, the suprachiasmatic nucleus (SCN) contains a biological clock that drives circadian rhythms in vivo and in vitro. Primary dissociated neuronal culture is a useful research tool, which allows cell-by-cell morphological and physiological study of the SCN.
Daan Ren, Joseph D. Miller
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Retinohypothalamic Projections and the Suprachiasmatic Nucleus in Birds
Brain, Behavior and Evolution, 1989Although many investigators have examined retinal projections in birds, there is uncertainty as to the location and identity of a retinorecipient nucleus in the hypothalamus of Aves. A direct retinohypothalamic projection to the medial hypothalamic suprachiasmatic nucleus in mammals is believed to play a role in the entrainment of circadian rhythms.
Rae Silver, Robert B. Norgren
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A Screen for Secreted Factors of the Suprachiasmatic Nucleus
2005The circadian clock in the suprachiasmatic nucleus (SCN) drives daily locomotor activity rhythms presumably by secreting diffusible factors whose target sites are accessible from the third ventricle of the hypothalamus. This article describes the methodology of a systematic molecular and behavioral screen to identify "locomotor factors" of the SCN.
Sebastian Kraves +3 more
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Schizophrenia as a possible dysfunction of the suprachiasmatic nucleus
Medical Hypotheses, 2010Psychosis and dreaming have many similarities, including delusions, hallucinations, bizarre thinking and perceptual distortions. This clinical observation has lead us to hypothesize that the suprachiasmatic nucleus (SCN), a hypothalamic center regulating sleep and wakefulness, is involved in the pathogenesis of schizophrenia.
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The Suprachiasmatic Nucleus and Other Pacemakers
1992A host of experiments involving mainly rats and hamsters have led to the recognition of the suprachiasmatic nuclei (SCN) of the hypothalamus as the site of an endogenous circadian oscillator in mammals (Rietveld and Groos 1980; Meijer and Rietveld 1989).Using an autoradiographic tracing method Moore (1973) demonstrated a direct neuronal connection ...
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The Suprachiasmatic Nucleus and the Circadian Timing System
2013The circadian timing system (CTS) in mammals may be defined as a network of interconnected diencephalic structures that regulate the timing of physiological processes and behavioral state. The central feature of the CTS is the suprachiasmatic nucleus (SCN) of the hypothalamus, a self-sustaining circadian oscillator entrained by visual afferents, input ...
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