Results 81 to 90 of about 14,490 (256)

Electrophysiology of hypothalamic magnocellular neurons in vitro: a rhythmic drive in organotypic cultures and acute slices

Frontiers in Neuroscience, 2016
Hypothalamic neurohormones are released in a pulsatile manner. The mechanisms of this pulsatility remain poorly understood and several hypotheses are available, depending upon the neuroendocrine system considered.
Jean-Marc eIsrael, Jean-Marc eIsrael, Stéphane H Oliet, Stéphane H Oliet, Philippe eCiofi, Philippe eCiofi   +5 more
doaj   +1 more source

18F‐ FDG PET Reveals a Nucleus Accumbens‐Centered Metabolic Network Correlating With Clinical Severity in Anti‐LGI1 Encephalitis

MedComm, Volume 6, Issue 12, December 2025.
This study provides a comprehensive 18F‐FDG PET‐based assessment of whole‐brain metabolism in the acute phase of anti‐LGI1 encephalitis. We identified a covariant metabolic network originating in the NAc; the strength of this network correlated positively with both clinical severity and cognitive impairment.
Binbin Nie, Xuan Xu, Wenyue Dong, Leilei Yuan, Hengri Cong, Yueta Ma, Huabing Wang, De‐Cai Tian, Linlin Yin, Tian Song, Yanxue Zhao, Guoqiang Chang, TianJie Lyu, Yun Liu, Wenping Ma, Fu‐Dong Shi, Lin Ai, Wangshu Xu   +17 more
wiley   +1 more source

Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations

Molecular Metabolism, 2022
Objective: The paraventricular nucleus of hypothalamus (PVN), an integrative center in the brain, orchestrates a wide range of physiological and behavioral responses.
Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui   +12 more
doaj   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, Volume 292, Issue 23, Page 6163-6181, December 2025.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders

Cell & Bioscience, 2023
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocellular neurons. The diverse presence and activity of oxytocin suggests a potential for this neuropeptide in the pathogenesis and ...
Sen Zhang, Ying-Dan Zhang, Dong-Dong Shi, Zhen Wang   +3 more
doaj   +1 more source

Early Life Mild Adversity Affects in a Sexually Dimorphic Way the Oxytocinergic System Reducing Close Social Interaction in Adult Male Rats

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
The oxytocinergic system is crucial in regulating social behaviors and is affected by early‐life experiences. We utilized a rat model of maternal neglect (Denial of Expected Reward, DER) and found that adult male, but not female, rats subjected to this experience as pups exhibited reduced levels of close social interaction (SI), which could be ...
Androniki Raftogianni, Lydia Pavlidi, Sofia Galeou, Theodora Kalpachidou, Fotini Stylianopoulou, Antonios Stamatakis   +5 more
wiley   +1 more source

Effects of nitric oxide on magnocellular neurons of the supraoptic nucleus involve multiple mechanisms

Brazilian Journal of Medical and Biological Research, 2014
Physiological evidence indicates that the supraoptic nucleus (SON) is an important region for integrating information related to homeostasis of body fluids. Located bilaterally to the optic chiasm, this nucleus is composed of magnocellular neurosecretory
M.P. da Silva, P.L. Cedraz-Mercez, W.A. Varanda   +2 more
doaj   +1 more source

Tuning the brain for motherhood: prolactin-like central signalling in virgin, pregnant, and lactating female mice [PDF]

, 2016
Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care.
Agustín-Pavón, Carmen, Lanuza, Enrique, Martínez García, Fernando, Salais López, Hugo   +3 more
core   +2 more sources

Mapping O‐linked glycosylation in the rat hypothalamus in pregnancy and lactation

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract Many maternal adaptations occur during pregnancy to support the metabolic demands of the developing fetus and to prepare for the continued metabolic demands of lactation. Among these maternal adaptations are changes in the hypothalamic areas that regulate energy homeostasis: the paraventricular nucleus (PVN), ventromedial hypothalamic nucleus (
Chantelle L. Murrell, Zsuzsanna Barad, Rachel S. Wallace, Jeffrey R. Erickson, Colin H. Brown, Rachael A. Augustine   +5 more
wiley   +1 more source

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [PDF]

, 2016
Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L.
Chen, Ling, Ding, Yu-Qiang, Huang, Ying, Lang, Bing, Lv, Zhu-Man, Niu, Xue-Yuan, Pruski, Michal, Qi, Cong-Cong, Shao, Can-Can, Song, Ning-Ning, Zhang, Chan, Zhang, Jin-Bao   +11 more
core   +2 more sources