Results 151 to 160 of about 1,901 (173)

Intramolecular interaction of SUR2 subtypes for intracellular ADP-induced Differential control of KATP channels

Intramolecular interaction of SUR2 subtypes for intracellular ADP-induced Differential control of KATP channels
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EXPRESSION AND PURIFICATION OF A SOLUBLE ESX-BINDING CORE DOMAIN OF SUR2

Preparative Biochemistry and Biotechnology, 2013
For HER2 overexpression, the ESX transcription factor must interact with both the HER2 promoter and Sur2, a subunit of human mediator complex, using its Ets domain and transactivation domain, respectively. HER2 overexpression is a marker of poor prognosis in various types of cancers. Thus, interfering with the ESX-Sur2 interaction has been suggested as
Kyung-Hwa Jeon, Kyu-Yeon Jun, Youngjoo Kwon   +2 more
exaly   +4 more sources

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target

Ageing Research Reviews, 2015
The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging.
Peter T Nelson, Gregory A Jicha, Wang-Xia Wang   +2 more
exaly   +6 more sources

Transcription Control by E1A and MAP Kinase Pathway via Sur2 Mediator Subunit

Science, 2002
Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans . We generated sur2 −/− embryonic
Jennitte Stevens, Gang Wang, Andrej Shevchenko   +2 more
exaly   +6 more sources

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels [PDF]

Journal of Clinical Investigation, 2002
K(ATP) channels couple the intracellular energy state to membrane excitability and regulate a wide array of biologic activities. K(ATP) channels contain a pore-forming inwardly rectifying potassium channel and a sulfonylurea receptor regulatory subunit (SUR1 or SUR2).
William A Chutkow, Matthew T Wheeler, Jonathan C Makielski   +2 more
exaly   +7 more sources

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Molecular characterization of human SUR2-containing KATP channels

Gene, 2000
The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR). mRNA for SUR2B was detected in a variety of tissues including brain, skeletal, cardiac and smooth muscle, whereas SUR2A message was restricted to cardiac and skeletal muscle.
Rachel Davis-Taber, Jorge D Brioni, James P Sullivan   +2 more
exaly   +3 more sources

Sulfonylurea receptor 2 (SUR2), intricate sensors for intracellular Mg‐nucleotides

BioEssays
AbstractSUR2, similar to SUR1, is a regulatory subunit of the ATP‐sensitive potassium channel (KATP), which plays a key role in numerous important physiological processes and is implicated in various diseases. Recent structural studies have revealed that, like SUR1, SUR2 can undergo ligand‐dependent dynamic conformational changes, transitioning between

exaly   +3 more sources

Abstract 10523: Involvement of Sur2/Kir6.1 In the Physiopathology of Pulmonary Arterial Hypertension

Circulation, 2022
Introduction: The ATP-sensitive K+ channels (KATP) regulatory subunit ABCC8 may be considered a new therapeutic target for pulmonary arterial hypertension (PAH). Hypothesis: We hypothesised that the second KATP regulatory subunit (ABCC9) contributes to PAH pathogenesis.
Hélène Le Ribeuz, Bastien Masson, Mary Dutheil, angele boet, Antoine Beauvais, Jessica Sabourin, Vincent Thomas de Montpreville, veronique capuano, Olaf M Mercier, Marc Humbert, David Montani, Fabrice Antigny   +11 more
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Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression

Molecular and Cellular Biochemistry, 2021
ATP-sensitive potassium (KATP) channels are participants of mechanisms of pathological myocardial remodeling containment. The aim of our work was to find the association of changes in the expression of Kir6.1, Kir6.2, SUR1, and SUR2 subunits of KATP channels with changes in heart function and structure during aging under conditions of the constant ...
Ruslan B. Strutynskyi, Serhii V. Goncharov, Lesya V. Tumanovska, Vasyl S. Nagibin, Victor E. Dosenko   +4 more
openaire   +2 more sources