Results 151 to 160 of about 2,021 (171)
ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target [PDF]
Ageing Research Reviews, 2015 The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging.
Colin Nichols +2 more
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Transcription Control by E1A and MAP Kinase Pathway via Sur2 Mediator Subunit
Science, 2002 Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans . We generated sur2 −/− embryonic
Jennitte Stevens +2 more
exaly +6 more sources
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels [PDF]
Journal of Clinical Investigation, 2002 K(ATP) channels couple the intracellular energy state to membrane excitability and regulate a wide array of biologic activities. K(ATP) channels contain a pore-forming inwardly rectifying potassium channel and a sulfonylurea receptor regulatory subunit (SUR1 or SUR2).
Matthew T Wheeler +2 more
exaly +7 more sources
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Molecular characterization of human SUR2-containing KATP channels
Gene, 2000The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR). mRNA for SUR2B was detected in a variety of tissues including brain, skeletal, cardiac and smooth muscle, whereas SUR2A message was restricted to cardiac and skeletal muscle.
Murali Gopalakrishnan +2 more
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Molecular and Cellular Biochemistry, 2021
ATP-sensitive potassium (KATP) channels are participants of mechanisms of pathological myocardial remodeling containment. The aim of our work was to find the association of changes in the expression of Kir6.1, Kir6.2, SUR1, and SUR2 subunits of KATP channels with changes in heart function and structure during aging under conditions of the constant ...
Vasyl Nagibin +2 more
exaly +3 more sources
ATP-sensitive potassium (KATP) channels are participants of mechanisms of pathological myocardial remodeling containment. The aim of our work was to find the association of changes in the expression of Kir6.1, Kir6.2, SUR1, and SUR2 subunits of KATP channels with changes in heart function and structure during aging under conditions of the constant ...
Vasyl Nagibin +2 more
exaly +3 more sources
Sulfonylurea receptor 2 (SUR2), intricate sensors for intracellular Mg‐nucleotides
BioEssaysAbstractSUR2, similar to SUR1, is a regulatory subunit of the ATP‐sensitive potassium channel (KATP), which plays a key role in numerous important physiological processes and is implicated in various diseases. Recent structural studies have revealed that, like SUR1, SUR2 can undergo ligand‐dependent dynamic conformational changes, transitioning between
exaly +3 more sources
Abstract 10523: Involvement of Sur2/Kir6.1 In the Physiopathology of Pulmonary Arterial Hypertension
Circulation, 2022Introduction: The ATP-sensitive K+ channels (KATP) regulatory subunit ABCC8 may be considered a new therapeutic target for pulmonary arterial hypertension (PAH). Hypothesis: We hypothesised that the second KATP regulatory subunit (ABCC9) contributes to PAH pathogenesis.
Hélène Le Ribeuz +11 more
openaire +1 more source
Alternative Splicing of sur2 Exon 17 Regulates Nucleotide Sensitivity of the ATP-sensitive Potassium Channel [PDF]
Journal of Biological Chemistry, 1999 ATP-sensitive potassium channels (KATP) are implicated in a diverse array of physiological functions. Previous work has shown that alternative usage of exons 14, 39, and 40 of the muscle-specific KATP channel regulatory subunit, sur2, occurs in tissue-specific patterns.
Charles Burant +2 more
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Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids
Sphingolipids are crucial components of cell membranes and serve as important signaling molecules. Ceramide, as the central hub of sphingolipid metabolism, plays a significant role in various biological processes, including the cell cycle, apoptosis, and cellular aging.
Xiaoyan Chen, Yanlu Wang
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Sphingolipids are crucial components of cell membranes and serve as important signaling molecules. Ceramide, as the central hub of sphingolipid metabolism, plays a significant role in various biological processes, including the cell cycle, apoptosis, and cellular aging.
Xiaoyan Chen, Yanlu Wang
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Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress [PDF]
Journal of Molecular and Cellular Cardiology, 2007 Adenosine triphosphate-sensitive potassium (K(ATP)) channels are thought to mediate the stress response by sensing intracellular ATP concentration. Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2).
Elizabeth McNally +2 more
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