Results 191 to 200 of about 206,828 (247)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

The Galectin Family in Colorectal Cancer: Integrating Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Perspectives. [PDF]

Biomedicines
Kozak K, Zajkowska M.
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

GSDMD Promotes Epithelial-Mesenchymal Transition and Lymph Node Metastasis in Cervical Cancer in vitro and in vivo. [PDF]

J Inflamm Res
Gao F, Yu H, Guo H, Fan J.
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study. [PDF]

Medicina (Kaunas)
Gruber D, Bina AM, Abu-Awwad A, Tinei OV, Abu-Awwad SA, Citu C, Ratiu A, Huidu B, Costescu S, Popa ZL.   +9 more
europepmc   +1 more source

Single-cell analysis and EpCAM-based microfluidic chip detection of PD-L1 on circulating tumor cells for prognostic prediction in epithelial ovarian cancer. [PDF]

Front Oncol
Zhang L, Lyu H, Tong X, Lou S.
europepmc   +1 more source

Utility of ultrasound biomicroscopy in detecting invasive ocular surface squamous neoplasia. [PDF]

Indian J Ophthalmol
Rehman O, Jain S, Das S.
europepmc   +1 more source

ZUP1 contributes to cisplatin resistance and treg-related signaling in non-small cell lung cancer. [PDF]

Sci Rep
Xiong W, Deng Z, Ding F, Xiao Z, Shi W, Gu G, Yan N.   +6 more
europepmc   +1 more source

Fibrothecoma with pseudo-carcinomatosis in a young woman: The radiologic pitfalls of Meigs syndrome and the importance of fertility-sparing surgery. [PDF]

Radiol Case Rep
Amara R, Tahouna MY, Kourchi H, Mouna N, Deflaoui T, Ziani H, Nasri S, Skiker I.   +7 more
europepmc   +1 more source