Results 101 to 110 of about 7,544,346 (399)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Tensile and fatigue properties of Inconel 718 at cryogenic temperatures [PDF]
Tests to determine the tensile and fatigue properties of Inconel 718 at cryogenic temperatures show that the alloy increases in strength at low temperatures, with very little change in toughness. The effect of surface finish and grain size on the fatigue
Malin, C. O., Schmidt, E. H.
core +1 more source
Electrochemical Surface Finishing
Electrochemical surface finishing is a highly scalable manufacturing process that traditionally uses viscous, non-aqueous and/or highly acidic electrolytes to achieve the desired surface profiles on metallic parts, with the addition of aggressive, hazardous chemical species to remove the oxide film on strongly passive materials.
E. J. Taylor, M. Inman
openaire +2 more sources
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
On-line optimisation and experimental design analysis for the investigations on the surface roughness produced by roller burnishing: a thesis submitted in partial fulfilment of the requirements for the degree of Master of Technology in Manufacturing and Industrial Technology at Massey University [PDF]
This thesis describes the improvement of the Surface finish of metals by a cold working, non-metal removal and plastic deformation process called roller burnishing. Roller burnishing is a popular finishing process.
Koorapati, Eshwara Prasad
core
Surface evaluation of carbon fibre composites using wavelet texture analysis
Strong and lightweight fibre reinforced polymeric composites now dominate the aerospace, marine and low-volume automotive sectors. The surface finish on exterior composite panels is of critical importance for customer satisfaction.
Hall, Wayne, Palmer, Stuart
core +1 more source
Surface finish, microhardness and microstructure of laser metal deposited 17-4PH stainless steel
Abiodun Bayode
openalex +2 more sources
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source

