Results 101 to 110 of about 7,544,346 (399)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Surface evaluations of a nanocomposite after different finishing and polishing systems for anterior and posterior restorations

open access: hybrid, 2021
Riccardo Monterubbianesi   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Tensile and fatigue properties of Inconel 718 at cryogenic temperatures [PDF]

open access: yes, 1969
Tests to determine the tensile and fatigue properties of Inconel 718 at cryogenic temperatures show that the alloy increases in strength at low temperatures, with very little change in toughness. The effect of surface finish and grain size on the fatigue
Malin, C. O., Schmidt, E. H.
core   +1 more source

Electrochemical Surface Finishing

open access: yesInterface magazine, 2014
Electrochemical surface finishing is a highly scalable manufacturing process that traditionally uses viscous, non-aqueous and/or highly acidic electrolytes to achieve the desired surface profiles on metallic parts, with the addition of aggressive, hazardous chemical species to remove the oxide film on strongly passive materials.
E. J. Taylor, M. Inman
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

On-line optimisation and experimental design analysis for the investigations on the surface roughness produced by roller burnishing: a thesis submitted in partial fulfilment of the requirements for the degree of Master of Technology in Manufacturing and Industrial Technology at Massey University [PDF]

open access: yes, 1998
This thesis describes the improvement of the Surface finish of metals by a cold working, non-metal removal and plastic deformation process called roller burnishing. Roller burnishing is a popular finishing process.
Koorapati, Eshwara Prasad
core  

Surface evaluation of carbon fibre composites using wavelet texture analysis

open access: yes, 2012
Strong and lightweight fibre reinforced polymeric composites now dominate the aerospace, marine and low-volume automotive sectors. The surface finish on exterior composite panels is of critical importance for customer satisfaction.
Hall, Wayne, Palmer, Stuart
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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