Results 71 to 80 of about 8,238,647 (329)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evaluation of the influence of laser quenching mode parameters on the quality of the surface and surface layer of machine parts (overview)

Омский научный вестник
This review provides an assessment of the influence of the parameters of the laser hardening mode on the quality of the surface and the surface layer.
S. V. Petrochenko, Q. Hao, X. Yu, K. Zhao   +3 more
doaj   +1 more source

Characterising gross plastic deformation in design by analysis [PDF]

, 2005
An investigation of three simple structures is conducted to identify and characterise the condition of gross plastic deformation in pressure vessel design by analysis.
Donald Mackenzie, Gerdeen, Hongjun Li, Lubliner, Moffat, Muscat, Save, Townley   +7 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Surface hardening of MIM porous metals by ultrasonic vibration assisted pressing

Manufacturing Review
Metal powder injection molding (MIM) has attracted attention as a cost-effective manufacturing method for serial producing complex designed micro metal parts.
Shimaoka Ryo, Yin Zidong, Tanaka Shigeo, Yang Ming   +3 more
doaj   +1 more source

Influence of Shot Peening on AlSi10Mg Parts Fabricated by Additive Manufacturing

Journal of Manufacturing and Materials Processing, 2018
The additive manufacturing (AM) of aluminum alloys promises to considerably enhance the performance of lightweight critical parts in various industrial applications.
Ahmed H. Maamoun, Mohamed A. Elbestawi, Stephen C. Veldhuis   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The effect of elevated temperature and tensile force loading on the relaxation of residual stresses in surface-hardened elements of the rod structure under creep conditions

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2019
A mathematical model for the relaxation of residual stresses in surface-hardened cylindrical elements of statically indefinable rod systems under creep conditions with elevated temperature and tensile force loading was developed.
Vladimir Pavlovich Radchenko, Ekaterina E Derevyanka   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An overview of laser surface modification of die steels [PDF]

, 2008
In recent years, surface modification using advanced heat source like laser has been replacing the conventional methods to produce amorphous microstructure via rapid solidification.
Aqida, S.N., Brabazon, Dermot, Maurel, M., Naher, Sumsun   +3 more
core